Sometimes solvents can be really useful, and other times they can turn a 30-minute drying step into an overnight drying step - but there are a whole lot of ways that solvents can ruin your day (or destroy your organs). Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist *Team* Producer - That Chemist (Joey)

Don't miss out on designing your dream set up with FlexiSpot. Use my exclusive code '24BDYTB30' for extra $30 off on E7, E7 Pro and E7L. Trust me, it's a rare treat! FlexiSpot E7 Pro standing desk: https://bit.ly/3YAPQuC - US https://bit.ly/3SEQnYJ - Canada MSG is the king of flavor... or is it? Let's discuss the science behind umami flavor, and taste the well known umami chemicals. Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist *Team* Producer - That Chemist (Joey) Writer - Scorp Lead Editor/Animator – David

Interested in boosting success rates in synthesis route design and prediction using the Predictive Retrosynthesis Tool from Reaxys? Find out more information here - https://beta.elsevier.com/products/reaxys/predictive-retrosynthesis?utm_campaign=prt-integration-ads&utm_source=thatchemist&utm_medium=video&dgcid=RN_AG_Sourced_400004103 Important Papers covers various chemical reactions, mechanisms, and research papers in the field of organic chemistry, providing examples and explanations for each research paper. In this video, I discuss major articles from fluorine chemistry which are widely overlooked by the majority of synthetic chemists - these are the bread and butter of fluorine chemistry. In this video, I focus on deoxy-fluorination strategies including direct deoxyfluorination, radical deoxyfluorination, and radical deoxy trifluoromethylation and difluoromethylation. Make sure you share this series with other chemists in your network, especially ones who don't usually watch YouTube! Support the Channel on Patreon - https://www.patreon.com/thatchemist Important Papers Playlist - https://youtube.com/playlist?list=PL6OLqxmk7RtyRkdJhXK8NWpT1krGNq1p4 ----------------------------------------- References: Deoxyfluorination review - 10.1039/d1qo00952d Deoxy-trifluoromethylation - 10.1021/jacs.2c04807 Deoxy-difluoromethylation - 10.1021/jacs.3c14460 -----------------------------------------

Chemistry can seem intimidating, but there are a lot of resources that make it easier to understand. In this video, I discuss numerous resources which have been valuable to myself and others when doing chemistry. Are there any good resources I missed? Drop a comment down below so that other mouth-pipetters can reap the benefits of your valuable experience. Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist *Team* Producer - That Chemist (Joey) *Links* Wikipedia - https://en.wikipedia.org/ PubChem - https://pubchem.ncbi.nlm.nih.gov/compound/Benzotrifluoride Chemistry LibreTexts - https://chem.libretexts.org/ PubPeer - https://pubpeer.com/ Reaxys - https://www.reaxys.com/ Scifinder - https://scifinder-n.cas.org/ The Chemical Rubber Company Handbook (pdfs can be found) Mayr's Database - https://www.cup.lmu.de/oc/mayr/reaktionsdatenbank2 Organic Chemistry Portal - https://www.organic-chemistry.org/ Google Patents - https://patents.google.com/ Google Scholar - https://scholar.google.com Molview - https://molview.org/ Wikipedia Chemical Structure Explorer - https://wikipedia.cheminfo.org/ Ullmann's Encyclopedia of Industrial Chemistry (pdfs can be found) SDBS - https://sdbs.db.aist.go.jp/ Bordwell pKa Table - https://organicchemistrydata.org/hansreich/resources/pka The Merck Index (pdfs can be found) Organic Syntheses - https://www.orgsyn.org/ NIST - https://webbook.nist.gov/ Ligma Baldrich Nomograph - https://rb.gy/h8j259 NotVoodooX - https://www.chem.rochester.edu/notvoodoo/ Scihub (mirrors change sometimes) - https://sci-hub.se eEROS - https://onlinelibrary.wiley.com/page/book/10.1002/047084289x/homepage/whatsnew.html Libgen - https://libgen.is/ Chemistry by Design - https://chemistrybydesign.oia.arizona.edu/app/ Reactionflash - https://www.elsevier.com/products/reaxys/higher-education/teaching-chemistry/reaction-flash

Go to https://TryFum.com/THATCHEMIST or scan the QR code and use code THATCHEMIST to get your free FÜM Base when you order your Journey Pack today! DO NOT MAKE EXPLOSIVES! In this video, we discuss the most dangerous explosives. We categorize them by their legality, danger, stability and toxicity. Even if you think you are able to safely prepare explosive compounds, you are probably wrong. There is a fluorine chemist named Darryl Desmarteau who was a chemistry professor researching energetic fluorinated materials. One day, when his researchers were out of the lab, he went to check on the lab, as any responsible supervisor does. As he was checking on his students' experiments, he reached out to take a closer look at one flask, and in that moment, it went off. When he ran to the lab phone to dial 911, the phone didn't respond, because he didn't have a hand anymore. Please consider the safety of yourself and those around you, as even trained experts have been maimed from experiments of scientific value. Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist Timestamps: Intro: 0:00 - 4:03 FÜM Ad: 4:03 - 4:57 Acetone Peroxide: 4:57 - 8:29 Blackpowder: 8:29 - 12:11 Flash Powder: 12:11 - 15:45 HMTD: 15:45 - 17:21 Acetylene: 17:21 - 20:19 Mercury (II) Fulminate: 20:19 - 22:11 Nitroglycerin: 22:11 - 23:51 PLX: 23:51 - 26:12 Trinitrotoluene (TNT): 26:12 - 29:22 RDX (Hexogen): 29:22 - 31:10 HMX (Octogen): 31:10 - 32:42 Ammonium Nitrate: 32:42 - 36:55 Picric Acid: 36:55 - 39:11 ETN & PETN: 39:11 - 41:06 Azides: 41:06 - 44:29 Outro: 44:29 - 44:53 FÜM Ad Outro: 44:53 - 44:56 *Team* Producer - That Chemist (Joey) Research/Scripting/Animator/Editor – David A huge thanks to the people who helped with this video, including: -Opossum Supremacist (reviewed completeness of tierlist, assisted in military-related questions) -Doyale (German translation, chemistry-related questions) -Ballerene & Indescension (SLAP round) -Nicolau, Laz, LWJ (picric acid corrections) -Mfernflower (Azidoazido azide enthusiast) *Links* All links can be found on pastebin, where there is no character limit: https://pastebin.com/k5ND9ECW

The greenhouse effect keeps life on our planet going, but if it gets too hot that ain't so good. In this video, we investigate the most common greenhouse gases, their global warming potentials (GWPs), and discuss concerns related to their emissions. Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist *Team* Producer - That Chemist (Joey)

Interested in boosting success rates in synthesis route design and prediction using the Predictive Retrosynthesis Tool from Reaxys? Find out more information here - https://beta.elsevier.com/products/reaxys/predictive-retrosynthesis?utm_campaign=prt-integration-ads&utm_source=thatchemist&utm_medium=video&dgcid=RN_AG_Sourced_400004103 Important Papers covers various chemical reactions, mechanisms, and research papers in the field of organic chemistry, providing examples and explanations for each research paper. In this video, I discuss major articles from fluorine chemistry which are widely overlooked by the majority of synthetic chemists - these are the bread and butter of fluorine chemistry. Make sure you share this series with other chemists in your network, especially ones who don't usually watch YouTube! Support the Channel on Patreon - https://www.patreon.com/thatchemist Important Papers Playlist - https://youtube.com/playlist?list=PL6OLqxmk7RtyRkdJhXK8NWpT1krGNq1p4 ----------------------------------------- References: Trifluoromethyltrimethylsilane: Nucleophilic Trifluoromethylation and Beyond - https://doi.org/10.1021/cr400473a Togni Reagents – Electrophilic CF3 - https://doi.org/10.1021/cr500223h Advances in the Development of Trifluoromethoxylation Reagents - https://pubs.acs.org/doi/10.3390/sym13122380 Efficient Difluoromethylation of Alcohols Using TMSCF2Br - https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.201611823 Org syn prep of togni reagent: https://doi.org/10.15227/orgsyn.088.0168 TMSCF2Br synthesis: https://doi.org/10.1016/j.jfluchem.2018.01.009 -----------------------------------------

Go to https://TryFum.com/THATCHEMIST or scan the QR code and use code THATCHEMIST to get your free FÜM Base when you order your Journey Pack today! Calories weigh heavily on a lot of people, but people try to reduce the intake of calories by using artificial sweeteners - let's talk about what they are and taste which one is best. If you’re looking for another video to watch, we also tasted a bunch of sugars in a previous video - Which Sugar Tastes the Best? (Sugar Lore) https://youtu.be/zcw7I5bT4Gk Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist Backup discord link: https://discord.gg/n5qtKjyRxN *Team* Producer - That Chemist (Joey) Lead Writer/Editor – @CiggySnake Cowriter - Scorp

Thanks to Listening for sponsoring this video! Get Listening using my link to let Listening know that you came from here! https://listening.1stcollab.com/that_chemist We tasted a bunch of bitter chemicals, and some of them were absolutely vile. Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist *Team* Producer - That Chemist (Joey) Writer - Scorp Lead Editor/Animator – @reformlabs1050 A big thanks to Brendin (FrawggyFresh https://www.twitch.tv/frawggyfresh) and Victor (Victor E) for suffering with me – also a big thank you to @MaxTheCatfish @ImKibitz and @CoffeeTimeJR for the PTC tasting at the end of the video!

Interested in boosting success rates in synthesis route design and prediction using the Predictive Retrosynthesis Tool from Reaxys? Find out more information here - https://beta.elsevier.com/products/reaxys/predictive-retrosynthesis?utm_campaign=prt-integration-ads&utm_source=thatchemist&utm_medium=video&dgcid=RN_AG_Sourced_400004103 Important Papers covers various chemical reactions, mechanisms, and research papers in the field of organic chemistry, providing examples and explanations for each research paper. In this video, I discuss four major review articles from four fields of radical chemistry which are widely overlooked by the majority of synthetic chemists. Make sure you share this series with other chemists in your network, especially ones who don't usually watch YouTube! I want to thank Maurice Hietkamp for his help with this episode :) Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist Backup Discord link - https://discord.gg/QWNPETtPcZ Important Papers Playlist - https://youtube.com/playlist?list=PL6OLqxmk7RtyRkdJhXK8NWpT1krGNq1p4 ----------------------------------------- References: Thirty Years of (TMS)3SiH: A Milestone in Radical-Based Synthetic Chemistry - https://doi.org/10.1021/acs.chemrev.8b00109 Discovery and Development of Organic Super-Electron-Donors - https://doi.org/10.1021/jo500071u Metallaphotoredox: The Merger of Photoredox and Transition Metal Catalysis - https://pubs.acs.org/doi/10.1021/acs.chemrev.1c00383 Radical Deoxyfunctionalisation Strategies - https://onlinelibrary.wiley.com/doi/abs/10.1002/ejoc.202200330 -----------------------------------------

This is an episode in the Extreme Chempilation series - expect mild profanity and stories that some viewers may find disturbing. One of this stories involves someone getting nitric acid in their eyes - what the heck is wrong with some of y'all DO NOT EAT OR DRINK LAB CHEMICALS! 💀💀💀 I want to give a huge thanks to all the supporters of the channel on Patreon! https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist *Team* Producer/Host - Joey (That Chemist) Production Assistant/Editor - Exergonick (MVP)

Now is the best time to buy the FlexiSpot Ergonomic Chair. 30 days free return, try it with confidence! Use code "C730" for $30 off! FlexiSpot C7 Premium Ergonomic Chair US: https://tinyurl.com/y8mp3tkv CA: https://tinyurl.com/bdhn8a7z Thanks to Flexispot for sponsoring this video! Lab clamps are still terrible - they can take their 3-fingers and grab onto tar for all I care. Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist Second Discord link if the first one is borked - https://discord.gg/QWNPETtPcZ ---------------------------------------------------------------------------------------------------------------------------------- Links to clamps et al discussed in this video (they are amazon.ca affiliate links but most of you are likely american so have fun finding them on amazon.com): smallrig 2 pack of clamps https://amzn.to/3TMDaOE smallrig blue mount https://amzn.to/3TMDaOE Neewer overhead mount https://amzn.to/3IKZJNc Neewer beefy clamp https://amzn.to/3vcZtUd JOBY magnetic tripod https://amzn.to/4apgCJe JOBY arms https://amzn.to/3vm3tl9 sound card tray https://amzn.to/43smDCw ----------------------------------------------------------------------------------------------------------------------------------

Cats are cool but I can't get too close to them - it's pretty dumb that being near a specific animal can make my immune system get triggered. Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist Second Discord link if the first one is borked - https://discord.gg/QWNPETtPcZ *Team* Editor/Producer/Thumbnail Artist - That Chemist (Joey) Writer - Scorp Lead Editor/Animator – @reformlabs1050 Helpful ppl: Trevor: Helped with information concerning the B-Cell Receptor Scorp: Help with Peptidoglycan Segment Ballerene: Help with Peptidoglycan segment Nick: Assisted with the Antigen Segment Matthew: Assisted with the Pink Planet in the New Tierlist format Ejkozan: Assistance with Ninhydrin & DCC part

Bacteria are the worst when they mess stuff up, but normally we need them, cause hey are pretty cool, but bacteria in hospitals suck - that's where SARS happens :/ ​⁠Check out @CiggySnake’s video here: https://youtu.be/N4WODXLL_fs Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist Second Discord link if the first one is borked - https://discord.gg/QWNPETtPcZ *Team* Editor/Producer/Thumbnail Artist - That Chemist (Joey) Writer/Lead Editor – @CiggySnake

This is an episode in the Extreme Chempilation series - expect mild profanity and stories that some viewers may find disturbing. Did you know that concentrated nicotine products are acutely toxic? Don't get nicotine on your family juuls DO NOT EAT OR DRINK LAB CHEMICALS! 💀💀💀 I want to give a huge thanks to all the supporters of the channel on Patreon! https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist *Team* Producer/Host - Joey (That Chemist) Production Assistant/Editor - Exergonick (MVP) Music (from FTL - Ben Prunty)

Let's be honest - Ligma Baldrich is robbing all of us and all they are doing is buying their chemicals from the vendors that you could also buy from! #stopsigma Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist Second Discord link if the first one is borked - https://discord.gg/QWNPETtPcZ *Team* Editor/Producer/Thumbnail Artist - That Chemist (Joey) Lead Editor – @reformlabs1050 (David) AI Wrangler - Bird Amazon Canada https://amazon.ca Amazon US https://amazon.com Ebay https://ebay.com Home Depot https://homedepot.com/ Mystic Moments https://www.mysticmomentsuk.com/ US Pigments Corp https://uspigment.com/ Bulk Supplements https://www.bulksupplements.com/ Onyxmet https://onyxmet.com/ (doesnt even show up when I googled it) Xenex https://www.xenexlabs.com/ Science Company https://www.sciencecompany.com/ Carolina Chemical https://carolinachemical.com/ Perfumer's Apprentice https://shop.perfumersapprentice.com/ Perfumers World https://www.perfumersworld.com/ Strem https://www.strem.com/ Fluorochem https://fluorochem.co.uk/ Combiblocks https://www.combi-blocks.com/ Ali Express https://www.aliexpress.com/ AK Scientific https://aksci.com/ Ligma Baldrich is not getting their URL listed Ambeed https://www.ambeed.com/ BLD https://www.bldpharm.com/ Enamine https://new.enaminestore.com/ Roth https://www.carlroth.com/com/en/ Oakwood https://oakwoodchemical.com/ (one time I tried to find their website on google when I was in oakwood, ON and they didnt show up at all) Voyageur https://www.voyageursoapandcandle.com/ Canadian Tire https://www.canadiantire.ca/en.html FB Marketplace https://www.facebook.com/marketplace/ Stellar Chemical Corp https://www.stellarchemicalcorp.com (doesnt even show up when I googled it) Activate Scientific https://shop.activate-scientific.com/ CIL https://isotope.com/ Synquest https://www.synquestlabs.com/ Bio-Basic https://www.biobasic.com/ Caledon https://caledonlabs.com/home.php Chemsavers https://chemsavers.com/ Etsy https://etsy.com Manchester Organic https://www.manchesterorganics.com/ Pell Wall https://pellwall.com/ Perfumer supply house https://perfumersupplyhouse.com/ ChemCraft https://chemcraft.su/ TCI https://www.tcichemicals.com/ TRC https://www.trc-canada.com/ Matrix Scientific https://www.matrixscientific.com (doesnt even show up when I googled it) Synthonix https://synthonix.com/ Plastic World https://plasticworld.ca/ Rona https://www.rona.com Home Hardware https://www.homehardware.ca/ Alfa Aesar http://www.alfa.com/ ThermoFischer https://www.thermofisher.com/ VWR https://www.vwr.com/ Blasta Deck is also not getting their website listed.

This is an episode in the Extreme Chempilation series - expect mild profanity and stories that some viewers may find disturbing. if you use lasers, please do not cut chlorinated plastics - honestly like if you dont know what a laser does to a specific material, maybe like you should do a google search first - maybe a good idea. DO NOT EAT OR DRINK LAB CHEMICALS! 💀💀💀 I want to give a huge thanks to all the supporters of the channel on Patreon! https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist *Team* Producer/Host - Joey (That Chemist) Production Assistant/Editor - Exergonick (MVP)

Subject: Josiah Newton Topic: PhD Thesis Defence Examination Stardate: December 8th, 2023 Outcome: Passed Brief: This was my PhD Thesis presentation, which was the culmination of my work as a researcher. If there is interest among the viewers, I may make a more detailed video in the future. Dr. Joey out. Complete thesis (online): https://summit.sfu.ca/item/37816

Thanks to Bespoke Post for sponsoring this video! New subscribers get 20% off their first box — go to https://bespokepost.com/thatchemist20 and enter code THATCHEMIST20 at checkout. What is chemistry? Well it turns out it's not just one thing - it's a whole bunch of things! Anal chemistry was a painful course to take, it was a real pain in the butt. Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist Second Discord link if the first one is borked - https://discord.gg/QWNPETtPcZ Editor/Producer/Thumbnail Artist - That Chemist (Joey) Lead Editor – @reformlabs1050 (David)

Important Papers covers various chemical reactions, mechanisms, and research papers in the field of organic chemistry, providing examples and explanations for each research paper. In this video, I discuss five important papers in organic synthesis that were published around October 2023. Make sure you share this series with other chemists in your network, especially ones who don't usually watch YouTube! I want to thank Maurice Hietkamp for his help with this episode :) Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist Backup Discord link - https://discord.gg/QWNPETtPcZ Important Papers Playlist - https://youtube.com/playlist?list=PL6OLqxmk7RtyRkdJhXK8NWpT1krGNq1p4 ----------------------------------------- References: Cephalotanin https://doi.org/10.1002/anie.202312599 Scandium https://doi.org/10.1021/acs.orglett.3c02734 Hydroamination https://doi.org/10.1021/jacs.3c08428 Bioisostere https://doi.org/10.1038/s41467-023-41298-3 NBS in DMF https://doi.org/10.1021/acs.oprd.3c00104 ----------------------------------------- Honorable mentions: Azoxy Compounds—From Synthesis to Reagents for Azoxy Group Transfer Reactions https://doi.org/10.1002/anie.202312031 Enantioselective Total Syntheses of (−)-Caulamidine D and (−)-Isocaulamidine D and Their Absolute Configuration Reassignment https://doi.org/10.1021/jacs.3c08714 Reductive N-Formylation of Nitroarenes Mediated by Rongalite https://doi.org/10.1021/acs.orglett.3c02839 Overcoming Deactivation of Amine-Based Catalysts: Access to Fluoroalkylated γ‑Nitroaldehydes https://doi.org/10.1021/jacs.3c08198 Deoxyfluorination of 1°, 2°, and 3° Alcohols by Nonbasic O−H Activation and Lewis Acid-Catalyzed Fluoride Shuttling https://doi.org/10.1021/jacs.3c08373 Desulfurative Borylation of Small Molecules, Peptides, and Proteins https://doi.org/10.1021/jacs.3c09081

Antlion Audio is giving 15% off for viewers who use code thatchemist at checkout - head over to https://antlionaudio.com/?ref=thatchemist to get your very own modmic wireless! Using that link helps support the channel :) Bleach really exists in your body? Propylene glycol disinfects the air? Apparently. Maybe that means people who vape are sterilizing the room? Fat rips season? Probably not. Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist Second Discord link if the first one is borked - https://discord.gg/QWNPETtPcZ *Team* Editor/Producer/Thumbnail Artist - That Chemist (Joey) Writer/Researcher - Scorp (Barry) Lead Editor – @reformlabs1050 (David) *Music* - A huge thanks to @S3RL for letting us use his music in the video! the song for the phenol montage is "Intensify - S3RL" Contact S3RL - https://withkoji.com/@S3RL

Subscribe to Curiosity Stream and start exploring the world around you! https://bit.ly/CuriosityStreamThatChemist1123 Plants can just poke you and then you need to go to the hospital? That sure is irritating. Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist Second Discord link if the first one is borked - https://discord.gg/QWNPETtPcZ *Team* Writer/Producer/Thumbnail Artist - That Chemist (Joey) Lead Writer/Editor – @CiggySnake

Go to https://ground.news/thatchemist to know where your information is coming from. Get 30% off their unlimited vantage plan or try out their pro plan for less than $1/month. Super bases are extremely strong bases, so strong that they get their own special designation. You must be super based if you are watching this video. Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist Second Discord link if the first one is borked - https://discord.gg/QWNPETtPcZ *Team* Writer/Producer/Thumbnail Artist - That Chemist (Joey) Lead Animator/Graphic Designer/Editor – David Vinamidine paper - https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.198711641 PKBH table - https://doi.org/10.2478/s11532-010-0044-9 Physico-Chemical Properties of Organosuperbases -https://doi.org/10.1002/9780470740859.ch2 Pandora's Phosphazene - https://onlinelibrary.wiley.com/doi/10.1002/anie.199313611 DMF/DMSO/DMA + NaH hazards - https://pubs.acs.org/doi/10.1021/acs.oprd.9b00276

You can get your very own Eco Funnels by going to https://www.calpaclab.com/eco-funnels/ and using code *thatchemist10* to get 10% off site-wide. Thanks to CP Lab Safety for supporting the channel! This is an episode in the Extreme Chempilation series - expect mild profanity and stories that some viewers may find disturbing. DO NOT EAT OR DRINK LAB CHEMICALS! 💀💀💀 I want to give a huge thanks to all the supporters of the channel on Patreon! https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist *Team* Producer/Host - Joey (That Chemist) Production Assistant/Editor - Exergonick

Sam (Chemiolis) claims to have made cubane, but how do we really know that he did? In this video we dive into Sam's cubane & geosmin samples, and we examine their NMR spectra. How should we do chemistry on YouTube? I discuss all this and more. Sam was honest and open in the preparation of this video - @Chemiolis @ExtractionsAndIre will make cubane eventually... A big thanks to ArgonLover for reviewing some of the research. Lead Editor/Animator - David Producer/Host - Joey (TC) Particle Animator - RobotChicken Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist Second Discord link if the first one is borked - https://discord.gg/QWNPETtPcZ Links to the videos where @Chemiolis makes cubane and geosmin: Cubane part 1 https://www.youtube.com/watch?v=zjp1aR6dSh4 Cubane part 2 https://www.youtube.com/watch?v=v6jqlL5ZT3M Geosmin https://www.youtube.com/watch?v=bl7K3lRPLYo

Interested in boosting success rates in synthesis route design and prediction using the Predictive Retrosynthesis Tool from Reaxys? Find out more information here - https://beta.elsevier.com/products/reaxys/predictive-retrosynthesis?utm_campaign=prt-integration-ads&utm_source=thatchemist&utm_medium=video&dgcid=RN_AG_Sourced_400004103 Important Papers covers various chemical reactions, mechanisms, and research papers in the field of organic chemistry, providing examples and explanations for each research paper. In this video, I discuss five important papers in organic synthesis that were published around September 2023. Make sure you share this series with other chemists in your network, especially ones who don't usually watch YouTube! I want to thank Maurice Hietkamp for his help with this episode :) Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist Backup Discord link - https://discord.gg/QWNPETtPcZ Important Papers Playlist - https://youtube.com/playlist?list=PL6OLqxmk7RtyRkdJhXK8NWpT1krGNq1p4 ----------------------------------------- References: Ethers from esters https://doi.org/10.1021/acs.orglett.3c02643 Sulfonamides from alcohols https://doi.org/10.1021/jacs.3c08216 Ethers from carbonyls https://doi.org/10.1021/acs.joc.3c00822 BMIDA acrolein https://doi.org/10.1021/acscatal.3c03474 Nitrosyl Triflate https://doi.org/10.1021/acs.orglett.3c02700 ----------------------------------------- Honorable mentions: Ergoline Synthesis https://doi.org/10.1021/acs.joc.3c01363 C−H Fluorination of Quinolines https://doi.org/10.1021/jacs.3c07119 Aryl (β,β′,β″-Trifluoro)-tert-butyl https://doi.org/10.1021/acs.orglett.3c02236 Carbenes Derived from Dichloromethane https://doi.org/10.1002/anie.202308913 The NBS DMF OPRD paper https://doi.org/10.1021/acs.oprd.3c00104

Super acids are extremely strong acids, so strong that they get their own special designation. Are you a registered super acid? Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist Second Discord link if the first one is borked - https://discord.gg/QWNPETtPcZ

Thanks to Bespoke Post for sponsoring this video! New subscribers get 20% off their first box of awesome — go to https://bespokepost.com/thatchemist20 and enter code THATCHEMIST20 at checkout. Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist Second Discord link if the first one is borked - https://discord.gg/QWNPETtPcZ Check out the selenium video from LabCoatz - https://www.youtube.com/watch?v=031vrZAMEHU A sneezing agent is also known as a 'sternutator' https://www.merriam-webster.com/dictionary/sternutator

This video discusses the scheduling of several common drugs within the United States. Hopefully this goes without saying - this video is not legal advice, usually if people want legal advice they pay a lawyer. ---------------------------------------------------------------------------------------- Clarifications: THC is Schedule II for Syndros, one formulation of THC, and THC is actually Schedule III for Marinol, another formulation of THC, but aside from these products, THC is Schedule I Sodium oxybate (a salt of GHB) is also listed as Schedule III even though GHB is Schedule I ----------------------------------------------------------------------------------------- https://en.wikipedia.org/wiki/Controlled_Substances_Act Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist You can check out Jordan's book "Bizarro: The Surreal Saga of America’s Secret War on Synthetic Drugs and the Florida Kingpins It Captured" here: https://www.amazon.com/Bizarro-Americas-Synthetic-Kingpins-Captured/dp/0520387953 (non-affiliate link)

Grab Atlas VPN for just $1.83/mo + 3 months extra before the SUMMER DEAL expires: https://get.atlasvpn.com/chemist 👈 #ad #atlasvpn This is an episode in the Extreme Chempilation series - expect mild profanity and stories that some viewers may find disturbing. DO NOT EAT OR DRINK OR SMOKE LAB CHEMICALS! 💀💀💀 I want to give a huge thanks to all the supporters of the channel on Patreon! https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist *Team* Producer/Host - Joey (That Chemist) Production Assistant/Editor - Exergonick

Interested in boosting success rates in synthesis route design and prediction using the Predictive Retrosynthesis Tool from Reaxys? Find out more information here - https://beta.elsevier.com/products/reaxys/predictive-retrosynthesis?utm_campaign=prt-integration-ads&utm_source=thatchemist&utm_medium=video&dgcid=RN_AG_Sourced_400004103 Important Papers covers various chemical reactions, mechanisms, and research papers in the field of organic chemistry, providing examples and explanations for each research paper. In this video, I discuss five important papers in organic synthesis that were published around August 2023. Make sure you share this series with other chemists in your network, especially ones who don't usually watch YouTube! I want to thank Maurice Hietkamp for his help with this episode :) Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist Backup Discord link - https://discord.gg/QWNPETtPcZ Important Papers Playlist - https://youtube.com/playlist?list=PL6OLqxmk7RtyRkdJhXK8NWpT1krGNq1p4 ----------------------------------------- References: First Paper (Tetrazoles) - https://doi.org/10.1021/acs.orglett.3c02470 Second Paper (Azetidines) - https://doi.org/10.1021/jacs.3c06710 Third Paper (Hamigeran NPs) - https://doi.org/10.1021/jacs.3c06031 Fourth Paper (Ozone with Copper) - https://doi.org/10.1126/science.adi4758 Fifth Paper (Dabconium Ylide) - https://doi.org/10.1021/acs.oprd.3c00175 Supplemental Reading: Cyclopropane-1,1-dicarboxylic acid - https://doi.org/10.15227/orgsyn.060.0066 Tomkinson's Reagent (eEROS) - https://doi.org/10.1002/047084289X.rn01983 ----------------------------------------- Honorable mentions: Nitro-Containing Cubanes - https://doi.org/10.1021/acs.joc.3c00384 β-Substituted Pyrroles/Furans - https://doi.org/10.1021/acs.joc.3c01145 Chlorodiazirines - https://doi.org/10.1002/anie.202305081 Divarasib - https://doi.org/10.1021/acs.oprd.3c00164 Fluorodetriazenation - https://doi.org/10.1021/acs.joc.3c01239 Thionoesters from thioamides -https://doi.org/10.1021/acs.orglett.3c02238

This is an episode in the Extreme Chempilation series - expect mild profanity and stories that some viewers may find disturbing. Summary This YouTube video recounts various chemical mishaps and incidents experienced by individuals working with hazardous chemicals. Kenny's ammonia mishap serves as a cautionary tale, highlighting the dangers of anhydrous ammonia exposure even with safety gear. Other stories include incidents with cleaning chemicals, accidental exposure to hazardous gases, flawed chemical storage, and improper handling of dangerous compounds. These incidents emphasize the importance of proper training, safety protocols, and awareness when working with chemicals. Highlights 🔥 Kenny's mishap with anhydrous ammonia underscores the risks of exposure, despite safety precautions. 🧪 Mixing cleaning chemicals and improper handling can lead to harmful consequences, as shown by various accounts. 💣 Accidental exposure to hazardous gases and chemicals, like cyanide and refrigerants, can result in burns, lasting damage, and dangerous reactions. ⚠️ Neglecting proper storage and handling of chemicals, such as nitric acid and fluorosurfactants, can lead to leaks and dangerous situations. 🛡️ Proper training, safety protocols, and awareness are crucial in preventing chemical incidents and ensuring personal safety when working with hazardous substances. (The 'Summary' and 'Highlights' were generated using Glarity) DO NOT EAT OR DRINK OR SMOKE LAB CHEMICALS! 💀💀💀 I want to give a huge thanks to all the supporters of the channel on Patreon! https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist *Team* Producer/Host - Joey (That Chemist) Production Assistant/Editor - Exergonick

In this video, I regale the stories of VidCon Anaheim, Open Sauce and Linus Tech Expo (LTX) 2023. Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist *Links to Conference Websites* https://www.vidcon.com/anaheim/ https://opensauce.live/ https://www.ltxexpo.com/ https://www.cheminst.ca/conference/canadian-chemistry-conference-and-exhibition-2023/ *Timestamps* 0:00 Intro 0:58 VidCon Lore 11:31 DisneyLand Side Quest 13:33 Open Sauce Lore 20:54 Important NileRed Lore 25:11 LTX Lore 32:34 Linus Media Group Office Tour *YouTube Creators Mentioned in the Video* Safety Third @safetythird Will Osman @williamosman Other Safety Third Hosts @allenpan @TheBackyardScientist (Safety Third guest - Jake Laser @JLaservideo) Kibitz @ImKibitz @KibitzandtheCaptain John and Hank Green @vlogbrothers (they have several channels) MatPat and Steph @GameTheory @FilmTheory @FoodTheory @StyleTheorists Safiya Nygaard @safiya Tyler Williams @tylerwilliams Colin & Samir @ColinandSamir MrBeast Channel @MrBeast (I also got to see Ben, Will & Dustin) Nigel @NileRed @NileBlue Isaiah @PryorGaming Stephen @littleremyfood @worldaquatica Zack Freedman @ZackFreedman (thanks for the B-roll used in the video Zack!) Cody's Lab @theCodyReeder Tom @ExplosionsAndFire @ExtractionsAndIre Drake @styropyro Ben @AppliedScience Adam Savage @tested Rene (YT Creator Liaison) @ReneRitchie Wren @CorridorCrew @Corridor Justin @thethoughtemporium Matt Gray @MattGrayYES Hamilton Morris @HamiltonMorris Medhi @ElectroBOOM LTT @LinusTechTips ShortCircuit @ShortCircuit Louis Rossman @rossmanngroup Douglas @DMS3TV Tech Linked @techlinked Braethorn @braethorn Sara Dietschy @saradietschy *Videos I Used in this Video* Safety Third VidCon clip https://www.youtube.com/watch?v=41JYVKSvHMY Hextraction https://www.youtube.com/watch?v=Iqz7ZDdP25A Tom cubane video https://www.youtube.com/watch?v=M0yXy49ADQ8 Tom hamilton morris quote https://www.youtube.com/watch?v=mV_daaldE_I My interview with Hamilton https://www.youtube.com/watch?v=dtGMyKlJheY Safety Third Mall Santa Video https://www.youtube.com/watch?v=USBX2pIU71k ^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^ Braethorn LTX tour https://www.youtube.com/watch?v=3ItcVjhVru0 Sara Dietschy LTX tour https://www.youtube.com/watch?v=yVbel7iw7ZI Kibitz also has a vidcon vlog and an LTX vlog available through his Patreon - https://www.patreon.com/imkibitz *Music* - A huge thanks to @S3RL for letting us use his music in the video! "MTC - S3RL" "I Will Pick You Up - S3RL feat Tamika" Contact S3RL - https://withkoji.com/@S3RL *Other Vlogs for Open Sauce* ElectroBoom https://www.youtube.com/watch?v=3ajADL92vuU (I couldn't find any other good ones - if you comment one and I see it, I may add more)

Interested in boosting success rates in synthesis route design and prediction using the Predictive Retrosynthesis Tool from Reaxys? Find out more information here - https://beta.elsevier.com/products/reaxys/predictive-retrosynthesis?utm_campaign=prt-integration-ads&utm_source=thatchemist&utm_medium=video&dgcid=RN_AG_Sourced_400004103 Important Papers covers various chemical reactions, mechanisms, and research papers in the field of organic chemistry, providing examples and explanations for each research paper. In this video, I discuss five important papers in organic synthesis that were published around June and July 2023. Make sure you share this series with other chemists in your network, especially ones who don't usually watch YouTube! I want to thank Maurice Hietkamp for his help with this episode :) Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist Backup Discord link - https://discord.gg/QWNPETtPcZ Important Papers Playlist - https://youtube.com/playlist?list=PL6OLqxmk7RtyRkdJhXK8NWpT1krGNq1p4 ----------------------------------------- References: First Paper (Methylenecyclobutanes) - https://doi.org/10.1039/D3SC01103H Second Paper (Beraprost) - https://doi.org/10.1021/jacs.3c04582 Third Paper (TBI-223) - https://doi.org/10.1021/acs.oprd.3c00148 Fourth Paper (Mitragynine Pseudoindoxyl ) - https://doi.org/10.1002/anie.202303700 Fifth Paper (Fluoromix) - https://doi.org/10.1126/science.adi1557 (Supplemental) Periodate cleavage of 1,2-diketones - https://pubs.acs.org/doi/10.1021/ja01510a009 Hazard of NaH with DMF/DMSO - https://youtu.be/IKmMESxYLFc ----------------------------------------- Honorable mentions: Conjugated Enals - https://doi.org/10.1021/acs.orglett.3c01576 Synthesis of (+)-KB343 - https://doi.org/10.1021/jacs.3c01991 C-N Cross-Coupling - https://doi.org/10.1021/jacs.3c05627 PCSK9 Inhibitor synthesis - https://doi.org/10.1021/acs.orglett.3c01635

Grab Atlas VPN for just $1.83/mo + 3 months extra before the SUMMER DEAL expires: https://get.atlasvpn.com/chemist 👈 #ad #atlasvpn This is the neurotransmitter tier list – I hope you find this video to be very stimulating! I guess this is neurotransmitter lore ;) Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist 0:00 Intro 4:53 Ad 6:15 Dopamine 9:30 GPCRs 14:39 Noradrenaline 17:42 Serotonin 21:25 Glutamate 24:55 GABA 27:00 Acetylcholine 29:35 Banana Outro 30:21 Dopamine (again?) *Team* Writer/Producer/Thumbnail Artist - That Chemist (Joey) Lead Animator/Graphic Designer/Editor – David Vesicle Animator - Chogi Lead Writer/Biochem Research - Exergonick (Nicholas) Writer/Biochem Research – Trev Chemistry Assistant - Maurice Technical Lead - Polygorg (Georg) Rigging/3D Systems Engineer - Robot Chicken *Acknowledgements* Ballerene for his ballin' biochem help *Music* - A huge thanks to @S3RL for letting us use his music in the video! "Dopamine - S3RL feat Sara" Contact S3RL - https://withkoji.com/@S3RL *References* Dopamine: https://www.kegg.jp/pathway/map00350+C03758, https://www.kegg.jp/pathway/map04728, https://www.genome.jp/pathway/hsa05012, https://www.kegg.jp/pathway/map05012+C03758 Noradrenaline: https://www.kegg.jp/entry/M00042 Serotonin: https://www.kegg.jp/pathway/map07211, https://www.kegg.jp/pathway/map04726 Tryptophan: https://www.kegg.jp/pathway/map04726+C00780 Glutamate: https://www.kegg.jp/kegg-bin/show_pathway?map04724 Gaba: https://www.kegg.jp/pathway/map04727 ACH: https://www.kegg.jp/pathway/map04725 Dopamine:Function & Symptoms: https://tinyurl.com/4cbw3ufd Acetylcholine in Learning and Memory: https://doi.org/10.1016/J.CONB.2006.09.002 Cholinergic Crisis: https://doi.org/10.1007/978-3-211-79280-3_237 Cholinesterase Inhibitors for Alzheimer’s: https://doi.org/10.1016/S0011-393X(03)00059-6 Myasthenia Gravis: https://doi.org/10.1212/CON.0000000000001161 Cholinergic Receptors: https://tinyurl.com/bdwec9j7 Otto Loewi: https://doi.org/10.11622/SMEDJ.2014002 Acetylcholine (ACh: https://tinyurl.com/5d4swfbm GABAergic Dysfunction: https://doi.org/10.1016/J.SEMCDB.2021.01.005 GABA Receptors: https://doi.org/10.1007/S11011-014-9560-1 The Neurobiology of Addiction: https://tinyurl.com/mryvu9bz Mechanism of Action - Benzodiazepine: https://tinyurl.com/3dycz4bu Anxiety Disorders and GABA Neurotransmission: https://doi.org/10.2147/NDT.S58841 Gamma-Aminobutyric Acid (GABA): https://tinyurl.com/mw58v55v Molecular Mechanisms GABAB: https://doi.org/10.1126/SCIADV.ABG3362 GABA and Glycine Receptors: https://tinyurl.com/2p9uvtrd GABA Receptor: https://tinyurl.com/yc6tv6cz NMDA Receptor-Dependent LTP/LTD: https://doi.org/10.1101/CSHPERSPECT.A005710 Glutamate and Depression: https://doi.org/10.5498/WJP.V11.I7.297 Glutamate Transporter 1: Target for the Treatment of Alcohol Dependence: https://doi.org/10.2174/092986712803530511 Glutamate: What It Is & Function: https://tinyurl.com/msk3z6we Glutamate Receptors: https://doi.org/10.1016/S0301-0082(01)00061-6 The History of (MSG): https://tinyurl.com/yt864se7 Serotonin Syndrome Case Report: https://doi.org/10.7759/CUREUS.22468 Brain Serotonergic Circuitries: https://doi.org/10.31887/DCNS.2010.12.4/YCHARNAY Abnormal Cells Constipation: https://doi.org/10.1080/003655299750025110 Serotonin: https://tinyurl.com/5d4swfbm Dopamine D1 Receptor: https://doi.org/10.3389/FNCEL.2021.806618 Dopamine in Motivational Control: https://doi.org/10.1016/j.neuron.2010.11.022 Norepinephrine: https://tinyurl.com/5cmbnma2 Adrenergic Neurons and Receptors: https://tinyurl.com/2s4fmw2m Noradrenergic Synapse: https://tinyurl.com/bdwec9j7 Adrenal Stress Hormones and Enhanced Memory for Emotionally Arousing Experiences: https://doi.org/10.1201/9781420008418.ch13 Dopamine and Noradrenaline in the Brain https://doi.org/10.3389/FNMOL.2019.00334 Noradrenergic Synapse: https://tinyurl.com/bdwec9j7 Dr Julius Axelrod: https://doi.org/10.1093/EURHEARTJ/EHAA200 Adrenal Gland: https://tinyurl.com/mv4jpauk Locus Coeruleus-Norepinephrine: https://doi.org/10.3389/FNAGI.2018.00127/BIBTEX Food-Related Reward Signals: https://doi.org/10.3402/FNR.V55I0.5955 Drugs Disrupt Presynaptic Dopamine Neurotransmission: https://doi.org/10.1016/J.NEURON.2011.02.010 Biochemistry, Dopamine Receptors: https://tinyurl.com/yc33pt4m Parkinson’s Disease: https://tinyurl.com/y84d2p7u Signaling Dopamine D1-like Receptor Activation: https://doi.org/10.1016/J.PHARMTHERA.2010.05.003 Ventral Tegmental Area, in Rat: https://doi.org/10.1016/j.neuroscience.2008.01.046 Arvid Carlsson: https://doi.org/10.4103/0019-5545.58907 Anatomy and Function of VTA : https://doi.org/10.3389/FNCIR.2022.867053/BIBTEX Dopamine in Motivational Control: https://doi.org/10.1016/j.neuron.2010.11.022 Relevant human Proteins found in RCSB PDB RCSB.org 10.1093/nar/28.1.235 And predicted proteins found at https://www.uniprot.org/

This is an episode in the Extreme Chempilation series - expect mild profanity and stories that some viewers may find disturbing. Summary This video discusses various dangerous and reckless activities involving chemicals, highlighting incidents such as smoking brake cleaner, touching a red-hot stand, chewing burnt flesh, a steam explosion, burning oneself with isopropanol, explosive experiments with acetone, glycerin mishaps, poor hygiene practices, broken glassware due to shaking a test tube, drinking pure alcohol, and handling dry ice unsafely. The dangers and potential injuries associated with these activities are emphasized throughout the video. Highlights 💥 Smoking brake cleaner as a fuel for a cigarette 🤚 Touching a red-hot stand and chewing burnt flesh 💣 Steam explosion due to a superheated experiment 🔥 Burns from handling isopropanol and explosive experiments with acetone 💦 Glycerin reacting with nitration mix, causing nitrogen dioxide release 🧤 Poor hygiene practices leading to chemical contamination 🧪 Accidental transfer of a chemical causing numbness in sensitive areas 🧪 Nail going through a test tube while shaking it 🍺 Drinking pure alcohol in a lab experiment 🧪 Ethanol theft and missing containers from chem stores ❄️ Dangerous effects of dry ice on skin and metal 💥 Unsafe handling of dry ice and liquid nitrogen leading to explosions (The 'Summary' and 'Highlights' were generated using Glarity) DO NOT EAT OR DRINK OR SMOKE LAB CHEMICALS! 💀💀💀 I want to give a huge thanks to all the supporters of the channel on Patreon! https://www.patreon.com/thatchemist The supporters on Patreon have decided to release the Patreon chempilations! We will be gradually releasing them after they get some minor editing. These will be known as Extreme Chempilations. This was the September 2022 Patreon Chempilation, until the Patrons changed the way things work :) Join the Community Discord! - https://discord.gg/thatchemist

This is an episode in the Extreme Chempilation series - expect mild profanity and stories that some viewers may find disturbing. In this video we have a story about TATP, which is a dangerous explosive chemical. Do not make explosives unless you know it is safe, legal and have professional training in the preparation of energetic materials. One person can threaten the lives of many people, and making explosives without taking appropriate precautions is irresponsible, dangerous, and is disrespectful to the safety and well-being of others. Summary This video discusses the dangers of making explosives without proper training and precautions. It tells a story of someone who made a large amount of TATP, a highly explosive chemical. The person shares their experiences and mistakes, including blowing up a snowman with 40 grams of TATP and making a batch using half a gallon of chemicals. The video emphasizes the extreme danger of TATP and advises against attempting such activities. Highlights 💣 Someone made large quantities of TATP, a dangerous explosive chemical. 💣 Blowing up a snowman with 40 grams of TATP. 💣 Mixing chemicals together and finding the jar boiling in the refrigerator. 💣 Pictures showing large amounts of TATP made by the person. 💣 The video warns against attempting such dangerous activities and emphasizes the extreme danger of TATP. (The 'Summary' and 'Highlights' were generated using Glarity) DO NOT EAT OR DRINK LAB CHEMICALS! 💀💀💀 I want to give a huge thanks to all the supporters of the channel on Patreon! https://www.patreon.com/thatchemist The supporters on Patreon have decided to release the Patreon chempilations! We will be gradually releasing them after they get some minor editing. These will be known as Extreme Chempilations. This was the September 2022 Patreon Chempilation, until the Patrons changed the way things work :) Join the Community Discord! - https://discord.gg/thatchemist

This is an episode in the Extreme Chempilation series - expect mild profanity and stories that some viewers may find disturbing. Summary This video discusses a story about someone who drank acetone, emphasizing the dangers of consuming chemicals not intended for ingestion. The person experienced unpleasant effects and shared their experiences online, promoting dangerous behavior. The video also mentions the toxicity of acetone, the potential health risks involved, and provides anecdotes about other chemical accidents and risky experiments. Highlights 💀 Someone drank 50 mL of acetone, which is highly dangerous and should not be replicated. 🧪 The person experienced unpleasant effects, including a thunderous headache and a sickeningly sweet aftertaste. 🚫 Drinking acetone is unsafe, and the individual lacked proper knowledge about its risks. 🤔 The person was driven by curiosity and the opportunity to get paid for performing dangerous experiments. 📚 Anecdotes are shared about other chemical accidents and risky behavior in laboratories. 🍌 A video is mentioned about using unripe banana water for chemical reactions, showcasing unusual experiments. (The 'Summary' and 'Highlights' were generated using Glarity) DO NOT EAT OR DRINK LAB CHEMICALS! 💀💀💀 I want to give a huge thanks to all the supporters of the channel on Patreon! https://www.patreon.com/thatchemist The supporters on Patreon have decided to release the Patreon chempilations! We will be gradually releasing them after they get some minor editing. These will be known as Extreme Chempilations. This was the August 2022 Patreon Chempilation, until the Patrons changed the way things work :) Join the Community Discord! - https://discord.gg/thatchemist

#standing desk #setup #flexispot Shop Flexispot standing desk here! US site: https://amzn.to/3onqlgI Canada site: https://amzn.to/43e3mDA Thanks to FlexiSpot for sponsoring this video! Placing an order using these links helps support the channel :) This is the third installment of the cursed molecules tier list series – don’t forget to drop a comment down below if you like the new 3D format! I don’t usually ask you magnificent viewers to like/subscribe/click that bell, but I guess if you don’t use the ‘Subscriptions’ tab to watch videos on YouTube, then you might not be shown when channels you are subscribed to finally upload a new video. If you want to see each and every video we upload, you can click the bell, but if you prefer to trust the algorithm, it can stay unclicked and the algorithms should show you our videos if other people (similar to you in the algorithms' eyes) enjoy the video and the algorithms think it’s a video you may enjoy watching. Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist _________ *Team* Writer/Producer - That Chemist (Joey) Graphic Designer/Editor/Animator – ReformLabs (David) Chemistry Assistant - Maurice Production Assistant - Aldous (Nicholas) 3D Systems Engineer - Robot Chicken Thumbnail Artists – RinFroggy & David Ad Co-host - Teresa _________ *Music* - A huge thanks to @S3RL for letting us use his music in the video! "All That I Need - S3RL feat Kayliana & MC Riddle" Contact S3RL - https://withkoji.com/@S3RL The music in the sponsored segment is "Bonfire - An Jone" _________ Molecules for this tier list: 1,3-bisohosphoglyceric acid, Novec 7700, Alloxan, Asparagusic acid, Beclabuvir, Cycasin, Methylazoxymethanol acetate, Diminazene, Empagliflozin, Epibatidine, Falcarindiol, Feprosidnine, Mesocarb, Timolol, Hipposudoric acid _________ *References* 1,3-bisohosphoglyceric acid http://content.febsjournal.org/cgi/content/abstract/186/1/265 Novec 7700 https://www.parallax-tech.com/all3m/novec-7700.pdf Alloxan http://www.orgsyn.org/demo.aspx?prep=CV4P0023 Asparagusic acid https://dmd.aspetjournals.org/content/29/4/539.full Beclabuvir https://www.clinicaltrials.gov/show/NCT03071133 Cycasin https://doi.org/10.1177%2F104063879300500337 Methylazoxymethanol acetate https://doi.org/10.1111%2Fj.1476-5381.2011.01386.x Diminazene https://doi.org/10.1016%2F0001-706X%2893%2990092-P Empagliflozin https://www.drugs.com/monograph/empagliflozin.html Epibatidine https://doi.org/10.1021%2Fnp900727e Falcarindiol https://doi.org/10.1016%2F0048-4059%2878%2990039-5 Feprosidnine https://pubmed.ncbi.nlm.nih.gov/7449977 Mesocarb https://pubmed.ncbi.nlm.nih.gov/4825943 Timolol https://www.drugs.com/monograph/timolol-eent.html Hipposudoric acid https://doi.org/10.1351%2Fpac200779040507 If you want a clip of just the outro to loop and watch - https://youtu.be/HkdmsOJKTmE (go listen to S3RL on Spotify or wherever you listen to music! He's one of my favorite artists and I am so stoked that he is letting us use his music on the channel)

Interested in boosting success rates in synthesis route design and prediction using the Predictive Retrosynthesis Tool from Reaxys? Find out more information here - https://www.elsevier.com/solutions/reaxys/predictive-retrosynthesis?utm_campaign=prt-integration-ads&utm_source=thatchemist&utm_medium=video&dgcid=RN_AG_Sourced_400004103 Important Papers covers various chemical reactions, mechanisms, and research papers in the field of organic chemistry, providing examples and explanations for each research paper. In this video, I discuss five important papers in organic synthesis that were published around May 2023. Anticipate that we will be taking a break for June 2023. Make sure you share this series with other chemists in your network, especially ones who don't usually watch YouTube! Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist Backup Discord link - https://discord.gg/QWNPETtPcZ Important Papers Playlist - https://youtube.com/playlist?list=PL6OLqxmk7RtyRkdJhXK8NWpT1krGNq1p4 ----------------------------------------- References: First Paper (Daphnillonin B) - https://pubs.acs.org/doi/pdf/10.1021/jacs.3c03755 Second Paper (Photocatalytic Denitrogenation) - https://pubs.acs.org/doi/pdf/10.1021/jacs.3c03634 Third Paper (Radical Hydrocarboxylation) - https://pubs.acs.org/doi/pdf/10.1021/jacs.3c03671 Fourth Paper (Esters to Ketones) - https://pubs.acs.org/doi/pdf/10.1021/acs.orglett.3c00992 Fifth Paper (Skeletal Editing) - https://pubs.acs.org/doi/pdf/10.1021/jacs.3c02616 ----------------------------------------- Honorable mentions: Benzocyclobutanes (https://doi.org/10.1126/science.adg5282) Nickel-Catalyzed Catellani (https://doi.org/10.1021/jacs.3c03780) Total Syntheses of (+)-Waixenicin A (https://doi.org/10.1021/jacs.3c03366) Total Synthesis of Pentamycin (https://doi.org/10.1021/jacs.3c03011) Addition to N‑Alkyl Nicotinate Salts (https://doi.org/10.1021/jacs.3c03048)

This is an episode in the Extreme Chempilation series - expect mild profanity and stories that some viewers may find disturbing. Summary This video shares various personal anecdotes and experiences related to dangerous chemical mishaps and accidents. The stories involve incidents such as inhaling hydrogen chloride gas, mishandling radioactive materials, chemical spills, and risky experiments with acids and bleach. The narratives emphasize the importance of safety precautions and responsible handling of chemicals. Highlights 💣 Inhaling hydrogen chloride gas caused a shocking and unpleasant experience. 📏 Generating anhydrous hydrogen chloride and its dangers. 🚧 Mishandling radioactive materials and the consequences. 🌪️ A chemical spill in a school caused a nauseating smell throughout the building. 💥 A bottle of acid exploded during a reckless experiment, causing a loud noise and potential harm. 🧪 Mixing bleach and acids resulted in the creation of dangerous gases. ⚠️ Clumsy lab technician spilled sulfuric acid, risking injury. 💥 Improper mixing of sulfuric acid and sodium hydroxide led to a geyser-like reaction. 🧪 Personal reflections on chemical mishaps and the importance of safety precautions. (The 'Summary' and 'Highlights' were generated using Glarity) I want to give a huge thanks to all the supporters of the channel on Patreon! https://www.patreon.com/thatchemist The supporters on Patreon have decided to release the Patreon chempilations! We will be gradually releasing them after they get some minor editing. These will be known as Extreme Chempilations. This was the May 2023 Patreon Chempilation, until the Patrons changed the way things work :) Join the Community Discord! - https://discord.gg/thatchemist

Interested in boosting success rates in synthesis route design and prediction using the Predictive Retrosynthesis Tool from Reaxys? Find out more information here - https://www.elsevier.com/solutions/reaxys/predictive-retrosynthesis?utm_campaign=prt-integration-ads&utm_source=thatchemist&utm_medium=video&dgcid=RN_AG_Sourced_400004103 Important Papers covers various chemical reactions, mechanisms, and research papers in the field of organic chemistry, providing examples and explanations for each research paper. In this video, I discuss five important papers in organic synthesis that were published around April 2023. Make sure you share this series with other chemists in your network, especially ones who don't usually watch YouTube! Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist Backup Discord link - https://discord.gg/QWNPETtPcZ Important Papers Playlist - https://youtube.com/playlist?list=PL6OLqxmk7RtyRkdJhXK8NWpT1krGNq1p4 ----------------------------------------- References: First Paper (Diethanolamine Boronates) - https://pubs.acs.org/doi/10.1021/acs.oprd.2c00342 Second Paper (Sulfones via Sulfonyl Fluorides) - https://pubs.acs.org/doi/pdf/10.1021/acs.orglett.3c00447 Third Paper (Deoxygenation of Alcohols) - https://doi.org/10.1002/anie.202300178 Fourth Paper (Room Temp Ar-Br Amination) - https://doi.org/10.1021/jacs.3c00500 Fifth Paper (Desymmetrization of Boronates) - https://doi.org/10.1021/jacs.3c01571 ----------------------------------------- Honorable mentions: Total Synthesis of (+)-Pedrolide - https://doi.org/10.1021/jacs.3c02113 Molybdenum(VI) Amide Activation - https://doi.org/10.1021/acs.joc.3c00218 Diastereoselective Synthesis of Cyclopropanes - https://doi.org/10.1002/ange.202303032 Tris(bicyclo[1.1.1]pentyl)phosphine - https://doi.org/10.1021/jacs.3c00885 Total Synthesis of Strempeliopidine - https://doi.org/10.1021/jacs.2c13146 Sulfonylation of Aryl Bromides - https://doi.org/10.1002/anie.202217623 Grayanane Diterpenoids - https://doi.org/10.1021/jacs.3c00753 Mechanochemical Birch - https://doi.org/10.1002/anie.202217723 Compact Rotaxane Superbases - https://doi.org/10.1021/jacs.3c01202 Dearomatization of arenes with tetrazinediones - https://doi.org/10.1021/jacs.3c02556 Enantioselective Divergent Syntheses of Cephalotaxus Alkaloids - https://doi.org/10.1021/jacs.3c01572 One-Bond-Nucleophilicity and -Electrophilicity Parameters: An Efficient Ordering System for 1,3-Dipolar Cycloadditions - https://pubs.acs.org/doi/full/10.1021/jacs.2c13872 – Mayr paper Mayr’s N-parameter Database - https://www.cup.lmu.de/oc/mayr/reaktionsdatenbank2/ Waveform-controlled Electrosynthesis - https://doi.org/10.1126/science.adf4762

Use code POGCHEMISTAPR50 for 50% off your first box at https://strms.net/ThatChemistFactorAprYT50 #ad Cubanes are a pretty neat class of molecules – in this video, we explore the applications of cubanes, and rank some impressive cubanes such as BUTTERCUBE! Summary In this, the host discusses Cubane, a cube-shaped molecule, and its potential applications in medicinal chemistry. Cubane is considered as a substitute for Benzene rings in new drug candidates. The 3D structure of Cubane allows for distinct interactions with target proteins or receptors. Additionally, Cubane can have different metabolites compared to Benzene. It is also explored in energetic materials. The video presents a tier list of various Cubane derivatives, highlighting their structures and uniqueness. Highlights 💡 Cubane is a cube-shaped molecule that medicinal chemists want to use as a substitute for Benzene rings in new drug candidates. 💡 Substituting a Benzene ring with Cubane in an active pharmaceutical ingredient (API) could potentially improve binding to the target. 💡 Cubane's 3D structure allows for different interactions in space, unlike the flat Benzene ring. 💡 Cubane derivatives can have different metabolites compared to Benzene, which is important for drug elimination from the body. 💡 Cubane is also explored in energetic materials, although its large-scale production poses challenges. 💡 The tier list of Cubane derivatives ranks them based on their impressive structures, with S tier being the most impressive. 💡 The video acknowledges the need for more commercially available and affordable Cubane derivatives to advance research and drug development. Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist *Team* Writer/Producer - That Chemist (Joey) Editor/Lead Animator - ReformLabs 3D Systems Engineer - Robot Chicken Thumbnail Artist - RinFroggy *Acknowledgements* Thanks to the people on Twitter who helped suggest cubane references! Especially Kitspiroplatin for the reference of the extremely long tetracubane iodide! I also want to acknowledge that Tom will eventually make cubane. *References* Tom’s Cubane Series https://www.youtube.com/playlist?list=PLnafk93vhO36cccP0p83hcop3xBTYkoTN Perfluorocubane https://www.youtube.com/watch?v=Tn9EANWD96s Chemiolis Click Chem https://www.youtube.com/watch?v=Ekbqix9fKXQ Casual Chemistry Click Chem https://www.youtube.com/watch?v=RqA4xQ4ujWI Cubane Review Articles: Cubanes in Med Chem http://doi.org/10.1021/acs.jmedchem.8b00888 Cubanes: 50 Years Later http://doi.org/10.1021/cr500523x Bicubyl https://pubs.acs.org/doi/10.1021/ja983441f bidentate cubane ligand https://doi.org/10.1055/s-0029-1217083 butter cubane https://doi.org/10.1016/S0040-4039(00)73295-3 carboxycubane thioxanthylglycine - https://worldwide.espacenet.com/patent/search?q=pn%3DWO2004024709 (page 48) cubane carboxylic acid https://doi.org/10.1002/chem.201901086 cubane dicarboxylic acid dimethyl ester https://doi.org/10.1055/s-0040-1705964 cubane https://doi.org/10.1055/s-1995-3961 cubene https://doi.org/10.1021/ja00229a057 cubyl phenyl ketone https://pubs.rsc.org/en/content/articlelanding/2019/OB/C9OB01238A cubyl triflate https://pubs.acs.org/doi/abs/10.1021/ja00164a063 cubylmethanol https://doi.org/10.1021/ol501750k dideuterocubane https://pubs.acs.org/doi/10.1021/jp953432i diethynyl cubane https://pubs.acs.org/doi/abs/10.1021/ja00096a016 diflucuburon https://doi.org/10.1002/anie.201510675 letepricube https://worldwide.espacenet.com/patent/search?q=pn%3DWO2011068881 mercury cubane insanity https://doi.org/10.1021/cr500523x (compound 71) methoxycarbonylcubane carboxylic acid - 10.1002/chem.201901086 octamethylcubane https://doi.org/10.1016/S0040-4039(00)73295-3 octacyclopropylcubane https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.200605150 octanitrocubane https://doi.org/10.1002/(SICI)1521-3773(20000117)39:2%3C401::AID-ANIE401%3E3.0.CO;2-P (this DOI sucks) octaphenylcubane https://pubs.acs.org/doi/abs/10.1021/jo01058a537 perfluorocubane https://doi.org/10.1126/science.abq0516 perfluorooctamethylcubane https://pubs.acs.org/doi/abs/10.1021/ja00430a050 tetracarbomethoxycubane https://link.springer.com/article/10.1007/BF01665973 tetrabromotetranitrocubane https://pubs.acs.org/doi/10.1021/jo971308k pedestal - https://doi.org/10.1002/anie.199214211 Molecules in this Tierlist Bicubyl, bidentate cubane ligand, butter cubane, carboxycubane thioxanthylglycine, cubane carboxylic acid, cubane dicarboxylic acid dimethyl ester, cubane, cubene, cubyl phenyl ketone, cubyl triflate, cubylmethanol, dideuterocubane, diethynyl cubane, diflucuburon, letepricube, mercury cubane insanity, methoxycarbonylcubane carboxylic acid, octamethylcubane, octacyclopropylcubane, octanitrocubane, octaphenylcubane, perfluorocubane, perfluorooctamethylcubane, tetrabromotetranitrocubane, tetracarbomethoxycubane, tin cubane insanity, extremely long cubane, lead cubane insanity

Thanks to Bespoke Post for sponsoring this video! New subscribers get 20% off their first box of awesome — go to https://bespokepost.com/thatchemist20 and enter code THATCHEMIST20 at checkout. This is the Vitamin Tierlist - vitamins play many important roles in our bodies and the biochemistry that vitamins do is pretty neat! Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist 0:00 Intro 2:45 sponsor 4:43 A 11:34 B1 17:24 B2 19:56 B3 22:45 B5 24:30 B6 27:09 B7 28:24 B9 30:29 B12 31:47 C 35:48 D 38:09 E 41:38 K *Team* Writer/Producer - That Chemist (Joey) Editor/Animator - ReformLabs Research/Production Assistant - Exergonick Technical Lead - Polygorg (Georg) 3D Systems Engineer - Robot Chicken *Acknowledgements* This video was made possible with help from several members of the TC Discord Community, especially Gocker (protein modelling expertise) & Ballerene (biochemistry expertise). Also @ExplosionsAndFire ! _________ *References* Neurotoxin Tierlist https://youtu.be/6fuCYXU4McQ Medicosis (corn tortillas) https://youtu.be/lPaU1ToTKz4?t=592 Vitamin B12 part 1 https://www.youtube.com/watch?v=YvEB05xdAy4 Vitamin B12 part 2 https://www.youtube.com/watch?v=AVi_awjWaP4 @MedicosisPerfectionalis https://youtube.com/playlist?list=PLYcLrRDaR8_dKo6Nu1Dw1efJGkDpuZGEy General nutrient information https://www.ncbi.nlm.nih.gov/books/NBK554545/ First vitamins https://doi.org/10.4066/AMJ.2013.1588. Essential Nutrient an overview https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/essential-nutrient Early vitamin paper https://doi.org/10.1246/NIKKASHI1880.32.4. Fat Soluble Vitamins https://www.ncbi.nlm.nih.gov/books/NBK534869/ Water Soluble Vitamins https://www.ncbi.nlm.nih.gov/books/NBK538510/ Vitamin K https://ods.od.nih.gov/factsheets/VitaminK-HealthProfessional/ Vitamin A and Carotenoids https://ods.od.nih.gov/factsheets/VitaminA-HealthProfessional/ Vitamin A and retinoid signaling https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679380/ Consequences of Vitamin A Deficiency https://doi.org/10.3390/IJMS21155570 Vitamin A Toxicity https://www.ncbi.nlm.nih.gov/books/NBK532916/ The Golden Rice Project https://www.goldenrice.org/ Thiamine https://ods.od.nih.gov/factsheets/Thiamin-HealthProfessional/ Dry Beriberi in a Man https://doi.org/10.1186/1752-1947-4-409 Beriberi. https://doi.org/10.1016/0306-9877(95)90115-9 Relevance of N-Heterocyclic Carbenes https://pubs.acs.org/doi/10.1021/jo300745e Thiamine Pyrophosphate an overview https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/thiamine-pyrophosphate Riboflavin https://ods.od.nih.gov/factsheets/Riboflavin-HealthProfessional/ Niacin https://ods.od.nih.gov/factsheets/Niacin-HealthProfessional/ Nixtamalization https://www.sciencedirect.com/topics/food-science/nixtamalization Nicotinic Acid Deficiency an overview https://www.sciencedirect.com/topics/medicine-and-dentistry/nicotinic-acid-deficiency Pantothenic Acid https://ods.od.nih.gov/factsheets/PantothenicAcid-HealthProfessional/ Vitamin B6 https://ods.od.nih.gov/factsheets/VitaminB6-HealthProfessional/ Biotin https://ods.od.nih.gov/factsheets/Biotin-HealthProfessional/ Folate https://ods.od.nih.gov/factsheets/Folate-HealthProfessional/ Vitamin B12 https://ods.od.nih.gov/factsheets/VitaminB12-HealthProfessional/ Vitamin C https://ods.od.nih.gov/factsheets/VitaminC-HealthProfessional/ Vitamin D https://ods.od.nih.gov/factsheets/VitaminD-HealthProfessional/ Vitamin E https://ods.od.nih.gov/factsheets/Vitamine-HealthProfessional/ Vitamin K https://ods.od.nih.gov/factsheets/vitamink-healthprofessional/ Vitamin digestion and absorption - https://www.kegg.jp/pathway/map04977 Biosynthesis of cofactors - https://www.kegg.jp/pathway/map0124 Pathway information: Vitamin A Retinol https://www.kegg.jp/pathway/map00830 Vitamin B1 Thiamine https://www.kegg.jp/pathway/map00730 Vitamin B2 Riboflavin https://www.kegg.jp/pathway/map00740 Vitamin B3 Niacin https://www.kegg.jp/pathway/map00760+C00153 Vitamin B5 Pantothenic Acid Beta alanine metabolism https://www.kegg.jp/pathway/map00410 CoA synthesis https://www.kegg.jp/pathway/map00770 Vitamin B6 Pyridoxine https://www.kegg.jp/pathway/map00750 Vitamin B7 Biotin https://www.kegg.jp/pathway/map00780 Vitamin B9 Folate/folic acid https://www.kegg.jp/pathway/map00790 Vitamin B12 Cobalamin https://www.kegg.jp/pathway/map00860+M00122 Vitamin C Ascorbic acid https://www.kegg.jp/pathway/map0005 Glutathione https://www.kegg.jp/pathway/map00480 Vitamin D steroid biosynthesis https://www.kegg.jp/pathway/map0010 Vitamin E Tocopherol https://www.kegg.jp/pathway/map00130+M00112 https://www.kegg.jp/pathway/map01110+M00112 Vitamin K Phytonadione https://www.kegg.jp/pathway/map00130+M00932 Relevant human Proteins found in RCSB PDB RCSB.org 10.1093/nar/28.1.235 And predicted proteins found at https://www.uniprot.org/

How realistic is the chemistry in breaking bad? Is it believable? I want to thank Rinfroggy and Molotay for their contributions to this project. Molotay - find out more at rb.gy/16go look at your calendar - anything important to do today? Oh yeah - rewatch all of breaking bad just to relate to a youtube video.

Thanks to ExpressVPN for sponsoring today's video. Go to https://strms.net/expressvpn_that_chemist1067 to get your first 3 months free! #ad Halogens are spooky, and they should always be treated with respect. In this video, we have lots of halogenated stories! This is the 31st chempilation If you support the channel on Patreon, you get access to monthly Patreon-exclusive chempilations. I just posted a brand new one yesterday! https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist Second Discord link if the first one is borked - https://discord.gg/QWNPETtPcZ Chempilation Playlist - https://www.youtube.com/playlist?list=PL6OLqxmk7Rtx_0L7pPT5tzLD7rT-93riO Reaction of aluminum with bromine - https://www.youtube.com/watch?v=KB_Nxay72ws #ad Producer/Lead Editor - TC Animator/Assistant Editor - ReformLabs Production Assistant - ToAldous

Interested in checking out the Predictive Retrosynthesis Tool from Reaxys? Find out more information here - https://www.elsevier.com/solutions/reaxys/predictive-retrosynthesis?utm_campaign=prt-integration-ads&utm_source=thatchemist&utm_medium=video&dgcid=RN_AG_Sourced_400004103 Important Papers covers various chemical reactions, mechanisms, and research papers in the field of organic chemistry, providing examples and explanations for each research paper. In this video, I discuss five important papers in organic synthesis that were published in March 2023. Make sure you share this series with other chemists in your network, especially ones who don't usually watch YouTube! Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist Backup Discord link - https://discord.gg/QWNPETtPcZ Important Papers Playlist - https://youtube.com/playlist?list=PL6OLqxmk7RtyRkdJhXK8NWpT1krGNq1p4 ----------------------------------------- References: First Paper – https://pubs.acs.org/doi/10.1021/jacs.3c01591 Second Paper – https://pubs.acs.org/doi/10.1021/jacs.2c12481 Third Paper – https://pubs.rsc.org/en/content/articlepdf/2023/sc/d3sc00001j Fourth Paper – https://pubs.acs.org/doi/10.1021/acs.oprd.2c00351 Fifth Paper – https://www.nature.com/articles/s41557-023-01136-x ----------------------------------------- Honorable mentions: Rh Carbenes - https://doi.org/10.1021/jacs.3c00012 Electron Transfer - https://doi.org/10.1038/s41929-023-00925-4 Overcrowding Aromaticity - https://doi.org/10.1038/s41557-023-01149-6 Electrochemical C-H Activation - https://doi.org/10.1126/science.adg2866

Go to https://strms.net/hellofresh_that_chemist-1067 and use code POGCHEMISTMAR60 for my special HelloFresh discount and to support my channel! #ad ————————————————— In this video, we explore several nerve-racking chemicals and discuss the biomechanics of nerves. I used to be a mouthpipetter like you, until I took a poisoned arrow in the knee. Intro 0:00 Sponsor 3:42 Ethanol 4:36 Tetrodotoxin 6:34 Botulinum toxin 7:34 Tetraethylammonium 8:36 Methylmercury 9:21 Toxiferine 11:05 n-Hexane 12:02 MPP+ 13:47 Anatoxin-A 14:56 Caramboxin 15:52 Turbocurarine chloride 17:09 Domoic acid 17:38 Strychnine 18:32 Annonacin 19:44 Tetraethyllead 20:38 Chlorpyrifos 21:50 TBPO 23:14 Neosaxitoxin 24:17 Carbon disulfide 25:33 TETS 26:29 Aldicarb 26:59 Batrachotoxin 28:06 Resiniferatoxin 28:49 5,7-dihydroxytryptamine 29:50 Oxidopamine 30:21 Para-chloroamphetamine 30:46 Penitrem A 31:23 Writer/Producer: That Chemist Editor/Animator: Reform Labs Researcher/Production Assistant: Aldous I also want to thank Ballerene from the Discord for early research. Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist ------------------------------------------------------------ References: Nerve Agent Tierlist - https://www.youtube.com/watch?v=5IFsaBBav78 neuron count in different species - https://doi.org/10.1073/PNAS.1201895109/ Nerves send signals - https://doi.org/10.1038/nn.4157. Neurotransmitters - https://mind.ilstu.edu/curriculum/neurons_intro/neurons_intro.html Synaptic Transmission - https://psych.athabascau.ca/html/Psych402/Biotutorials/animations/synapse.shtml Neurotransmitter reuptake - https://doi.org/10.1101/CSHPERSPECT.A005595. Hormones, Peptides, and Neurotransmitters and Their Role in Obesity - https://doi.org/10.1177/1559827617716376. Melatonin - https://doi.org/10.3390/BRAINSCI9100285. The Role of Brain Gaseous Neurotransmitters in Anxiety - https://doi.org/10.1007/S43440-021-00242-2. Reactive Oxygen Species - https://doi.org/10.3389/FCELL.2021.628157/BIBTEX. Alcohol, Oxidative Stress, and Free Radical Damage - https://doi.org/10.1079/pns2006496. Toxicity of organomercury compounds - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3183295/ Tetrodotoxin - https://www.cdc.gov/niosh/ershdb/emergencyresponsecard_29750019.html BOTULINUM TOXIN - https://doi.org/10.4103/0019-5154.60343. Tetraethylammonium - https://doi.org/10.1016/B978-0-12-801238-3.97466-X. Toxiferine - https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/toxiferine N-Hexane - https://doi.org/10.1136/jnnp.50.3.269. MPP+ - https://www.sciencedirect.com/topics/medicine-and-dentistry/mpp Epa, U.; of Water, O. Health Effects Support Document for the Cyanobacterial Toxin Anatoxin-A Office of Water Mail Code 4304T United States Environmental Protection Agency. 2015. Elucidating the Neurotoxicity of the Star Fruit - https://doi.org/10.1002/ANIE.201305382. Tubocurarine Chloride - https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/tubocurarine-chloride The Phycotoxin Domoic Acid as a Potential Factor for Oxidative Alterations Enhanced by Climate - https://doi.org/10.3389/FPLS.2020.576971/BIBTEX. Strychnine - https://www.sciencedirect.com/topics/medicine-and-dentistry/strychnine Tetraethyllead - http://dx.doi.org/10.1136/oem.16.3.191 https://link.springer.com/article/10.1007/s13181-010-0034-5 https://doi.org/10.2131/jts.15.SupplementIV_125 Chlorpyrifos - https://www.epa.gov/ingredients-used-pesticide-products/chlorpyrifos Tetramethylenedisulfotetramine -https://doi.org/10.1073/PNAS.1407379111/SUPPL_FILE/PNAS.1407379111.SAPP.PDF. Structure-Toxicity Relationships of 1-Substituted-4-Alkyl-2,6,7-Trioxabicyclo[2.2.2.]Octanes - https://doi.org/10.1016/0041-008X(79)90323-5. Neosaxitoxin - https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/neosaxitoxin Carbon Disulfide - https://pubmed.ncbi.nlm.nih.gov/23331301/ https://pubmed.ncbi.nlm.nih.gov/27900598/ https://doi.org/10.1515/dmdi.1988.6.3-4.275 Tetramethylenedisulfotetramine - https://doi.org/10.3390/TOXICS6030051. Aldicarb - https://www.sciencedirect.com/topics/neuroscience/aldicarb Batrachotoxin - https://www.sciencedirect.com/topics/neuroscience/batrachotoxin Resiniferatoxin - an overview | ScienceDirect Topics https://www.sciencedirect.com/topics/neuroscience/resiniferatoxin 5,7-Dihydroxytryptamine - https://doi.org/10.1016/j.brainres.2007.02.052 Chloramphetamine - https://doi.org/10.1016/0006-2952(86)90332-1 Oxidopamine - https://www.sciencedirect.com/topics/neuroscience/oxidopamine Penitrem A - https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/penitrem-a

Important Papers covers various chemical reactions, mechanisms, and research papers in the field of organic chemistry, providing examples and explanations for each research paper. In this video, I discuss five important papers in organic synthesis that were published in February 2023. Make sure you share this series with other chemists in your network, especially ones who don't usually watch YouTube! Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist Backup Discord link - https://discord.gg/QWNPETtPcZ Important Papers Playlist - https://youtube.com/playlist?list=PL6OLqxmk7RtyRkdJhXK8NWpT1krGNq1p4 ----------------------------------------- References: First Paper – https://doi.org/10.1021/acs.orglett.2c03840 Second Paper – https://doi.org/10.1021/jacs.2c13396 Third Paper – https://doi.org/10.1021/jacs.2c13245 Fourth Paper – https://doi.org/10.1021/jacs.2c12699 Fifth Paper – https://doi.org/10.1021/jacs.2c13502 ----------------------------------------- Honorable mentions: Hydroperoxides - https://doi.org/10.1021/acs.orglett.2c04233 Zizaene - https://doi.org/10.1021/jacs.2c10923 Tropylium - https://doi.org/10.1021/acscatal.2c06016 BCBs - https://doi.org/10.1021/jacs.2c13740 Alpha-fluorination - https://doi.org/10.1021/acs.orglett.3c00313 Germanes - https://doi.org/10.1021/jacs.2c12062 S(O)CF3 - https://doi.org/10.1021/acs.orglett.2c04243 Cyclobutanes - https://doi.org/10.1021/acs.joc.2c02564 Lysergic - https://doi.org/10.1021/jacs.2c13289 Vinyl bromide metathesis - https://doi.org/10.1021/jacs.2c13520 Thianthrene benzyne - https://doi.org/10.1021/jacs.2c13007

How bad is it? Sorta bad, but it has impacted the lives of many local people greatly. ​@PracticalEngineeringChannel has a better up-to-date video on this: https://www.youtube.com/watch?v=uPno1IVTkFY A lot of people asked me to make this video, I think I have had over 30 people request this video. A huge thanks to Aldous, Mfernflower, Turtle, and Opossum Supremacist for their help :) I also want to thank Nathan. Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist Second Discord link if the first one is borked - https://discord.gg/QWNPETtPcZ ---------------------------------------------------------------------------------------------------------------------------------- References: Wikipedia has the most reliable information; it also has links to all the main sources (good luck searching literally anywhere else, unless you want to spend 2 days chasing leads, like I did) - https://en.wikipedia.org/wiki/2023_Ohio_train_derailment train manifest - https://response.epa.gov/sites/15933/files/TRAIN%2032N%20-%20EAST%20PALESTINE%20-%20derail%20list%20Norfolk%20Southern%20document.pdf https://response.epa.gov/site/site_profile.aspx?site_id=15933 propylene glycol MSDS - https://www.sigmaaldrich.com/CA/en/sds/sial/p4347 ethylhexyl acrylate MSDS - https://www.sigmaaldrich.com/CA/en/sds/aldrich/290815 butyl acrylate MSDS - https://www.sigmaaldrich.com/CA/en/sds/aldrich/234923 ----------------------------------------------------------------------------------------------------------------------------------

We've been playing around with AI for a while - what can it do? Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist Second Discord link if the first one is borked - https://discord.gg/QWNPETtPcZ I used ChatGPT, DALL-E, and Descript for this video. https://chat.openai.com/ https://labs.openai.com/ https://www.descript.com/ ---------------------------------------------------------------------------------------------------------------------------------- References: @TomScottGo - https://www.youtube.com/watch?v=jPhJbKBuNnA @JonTronShow - https://www.youtube.com/watch?v=a-xGt-YvYys @thespiffingbrit - https://www.youtube.com/watch?v=PVbOPhTcTxA @Daxflame - https://www.youtube.com/watch?v=gqe_s_Q6xkU ----------------------------------------------------------------------------------------------------------------------------------

Head over to https://drinkwize.com and use the code THATCHEMIST to earn 20% off your first order! In this video, I try harder than usual to pronounce plant names correctly. I also discuss several uncanny molecules, and rank them from most to least uncanny. Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist Second Discord link if the first one is borked - https://discord.gg/QWNPETtPcZ ------------------------------------------------------------ References: Pyrimethamine nurd rage https://www.youtube.com/watch?v=5kZi3J2S52E Triangulenes https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.200461166 Amabiline https://doi.org/10.1071%2FCH9672499 Folinic acid https://www.drugs.com/monograph/leucovorin-calcium.html Meralluride https://doi.org/10.1016%2F0021-8707%2853%2990063-X https://doi.org/10.1536%2Fihj.8.743 Peroxyacetyl nitrate https://doi.org/10.1016%2FB978-0-12-382225-3.00433-3 Hyperforin https://pubchem.ncbi.nlm.nih.gov/compound/441298 Graphullerene https://www.nature.com/articles/s41586-022-05401-w Calicheamicin https://doi.org/10.7164%2Fantibiotics.42.558 https://doi.org/10.1073%2Fpnas.89.10.4608 https://pubs.acs.org/doi/10.1021/ja00051a063 https://doi.org/10.1126%2Fscience.1086695 Miroestrol https://www.ftc.gov/os/2002/12/vdicmp.pdf Nevirapine https://www.drugs.com/monograph/nevirapine.html Hypericin http://pharmaxchange.info/press/2012/12/pharmacognosy-of-st-johns-wort/ JWH-176 https://doi.org/10.2174%2F0929867054020864 Xylindein http://gallica.bnf.fr/ark:/12148/bpt6k30232/f110.image Quinhydrone https://doi.org/10.1016%2Fb978-0-12-555160-1.50017-4 Monocrotaline https://doi.org/10.1152%2Fajplung.00212.2011 Longamide B https://doi.org/10.1021/jo051555l https://doi.org/10.1016/s0305-1978(00)00016-8 Lamotrigine https://www.drugs.com/monograph/lamotrigine.html Nitromemantine https://doi.org/10.1016%2Fj.ceca.2009.12.009 https://doi.org/10.1038%2Fnrd1958 Atractyloside https://doi.org/10.1016%2FS0278-6915%2898%2900002-7 https://doi.org/10.1016%2Fj.jep.2004.11.025 https://doi.org/10.1097%2F00007691-200012000-00001 Phytic acid https://doi.org/10.1002%2Fmnfr.200900099 Triclofos https://www.sciencedirect.com/science/article/pii/B9780080552323627977 Ichyothereol https://doi.org/10.1021%2Fjo0104532 https://doi.org/10.1021%2Fja00950a044 Sivifene http://adisinsight.springer.com/drugs/800002477 ------------------------------------------------------ All molecules for this Tierlist: Triangulanes, Amabiline, Folinic acid, Meralluride, Peroxyacetyl nitrate, Hyperforin, Graphullerene, Calicheamicin, Miroestrol, Nevirapine, Hypericin, JWH-176, Xylindein, Quinhydrone, Agelongine, Monocrotaline, Longamide B, Lamotrigine, Nitromemantine, Atractyloside, Phytic acid, Triclofos, Ichyothereol, Sivifene

Download ReactionFlash for free using the following links: Apple App Store: https://apps.apple.com/app/apple-store/id432080813?pt=119296909&ct=ThatChemist-Ad4&mt=8 Google Play Store: https://play.google.com/store/apps/details?id=ch.reaxys.reactionflash&hl=en_GB&gl=US&utm_campaign=reactionflash&utm_source=thatchemist-ad3&utm_medium=video&utm_content=descriptionlink&utm_term=ad4 This video is sponsored by Reaxys. In this video, I discuss five important papers in organic synthesis that were published in January 2023. Make sure you share this series with other chemists in your network, especially ones who don't usually watch YouTube! Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist Backup Discord link - https://discord.gg/QWNPETtPcZ Important Papers Playlist - https://youtube.com/playlist?list=PL6OLqxmk7RtyRkdJhXK8NWpT1krGNq1p4 ----------------------------------------- References: First Paper – https://doi.org/10.1021/jacs.2c13207 Second Paper – https://doi.org/10.1021/jacs.2c11453 Third Paper – https://doi.org/10.1021/jacs.2c11295 Fourth Paper – https://doi.org/10.1021/acscatal.2c05293 Fifth Paper – https://doi.org/10.1021/acs.orglett.2c04144 -------------------------------------- Honorable Mentions: Ca-H - https://doi.org/10.1021/acs.joc.2c02800 Formylation - https://doi.org/10.1021/acs.joc.2c02576 Addition to aldehydes - https://doi.org/10.1021/acs.joc.2c01843 I(III) diazo reagents - https://doi.org/10.1021/acs.orglett.2c04114 1,3,4-Oxadiazolines - https://doi.org/10.1021/acscatal.2c05319 Methylenation - https://doi.org/10.1021/acs.joc.2c02637 NHC boryl radical - https://doi.org/10.1021/jacs.2c10444 Nitroarenes - https://doi.org/10.1021/jacs.2c12450

Get 20% OFF + Free shipping + 2 FREE GIFTS @Manscaped with promo code THATCHEMIST at https://manscaped.com! #teammanscaped - https://mnscpd.com/thatchemist This video is packed with more wild lab stories - hopefully you never end up facing the same fate these people did! This is the 30th chempilation If you support the channel on Patreon, you get access to monthly Patreon-exclusive chempilations. I just posted a brand new one yesterday! https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist Second Discord link if the first one is borked - https://discord.gg/QWNPETtPcZ Chempilation Playlist - https://www.youtube.com/playlist?list=PL6OLqxmk7Rtx_0L7pPT5tzLD7rT-93riO Thumbnail was made by DALL-E #ad

In this video, I discuss several carcinogens and discuss their designations according to the IARC (International Agency for Research on Cancer). Don't be a nugget, minimize your exposure to carcinogens! Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist Second Discord link if the first one is borked - https://discord.gg/QWNPETtPcZ ------------------------------------------------------------ References: Medlife crisis video – https://www.youtube.com/watch?v=yNzQ_sLGIuA Chloracne - https://upload.wikimedia.org/wikipedia/commons/5/5a/Chloracne-in-herbicide-worker.png Hamiltons pharmacopeia - https://www.youtube.com/watch?v=zBYsY7g24r0 Risky chemicals Tierlist - https://www.youtube.com/watch?v=QfOYfBeP5KE IARC Monographs https://publications.iarc.fr/Book-And-Report-Series/Iarc-Monographs-On-The-Identification-Of-Carcinogenic-Hazards-To-Humans Aristolochic acid I 3:37 https://doi.org/10.1016%2Fj.jep.2009.05.028 https://www.hongkongfp.com/2017/10/19/across-asia-liver-cancer-linked-herbal-remedies-study/ https://www.fda.gov/Food/DietarySupplements/Alerts/ucm096388.htm IARC V100A Acetaldehyde 8:09 http://www.epa.gov/chemfact/s_acetal.txt https://doi.org/10.1080%2F00365520902912563 https://doi.org/10.1371%2Fjournal.pone.0140013 IARC V100E Aflatoxins 11:11 https://doi.org/10.3109%2F10408444.2011.575766 IARC V100F 4-Aminobiphenyl 12:34 https://www.ncbi.nlm.nih.gov/books/NBK304408/ https://doi.org/10.1016%2F0006-2952%2896%2900165-7 https://doi.org/10.1002%2Fijc.21173 IARC V100F Arecoline 13:16 https://doi.org/10.1016%2FS0014-827X%2801%2901091-6 https://pubmed.ncbi.nlm.nih.gov/3600615 IARC V85 Agaritine 14:20 https://doi.org/10.1080%2F02652030802039903 IARC V31 Benzene 14:55 https://doi.org/10.1289%2Fehp.93100293 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1568107/ IARC V100F Benzidine 16:33 http://www.cancer.org/docroot/PED/content/PED_1_3x_Known_and_Probable_Carcinogens.asp?sitearea=PED https://web.archive.org/web/20100821232316/http://www.epa.gov/oppt/existingchemicals/pubs/actionplans/benzidine.html IARC V29 Benzo[a]pyrene 17:28 https://doi.org/10.1016%2FS0278-6915%2800%2900158-7 https://books.google.com/books?id=Fw_G7Sk382IC&q=Benzo%28a%29pyrene-7%2C8-dihydrodiol-9%2C10-epoxide+cas&pg=PA102 IARC V92 Bis(chloromethyl)ether/chloromethyl methyl ether 18:30 https://doi.org/10.1002%2F14356007.a10_023 https://doi.org/10.1016%2Fs0013-9351%2889%2980059-3 https://ntp.niehs.nih.gov/ntp/roc/content/profiles/bis_chloromethyletherandtechnical-gradechloromethylmethylether.pdf https://youtu.be/ErLv93PgiuM http://www.epa.gov/iris/subst/0245.htm IARC V100F Butadiene 20:01 https://doi.org/10.1002%2F14356007.a04_431.pub2 https://doi.org/10.1016%2FS1470-2045%2807%2970235-8 IARC V100F Cyclosporine 20:43 https://www.drugs.com/monograph/cyclosporine.html https://www.ncbi.nlm.nih.gov/books/NBK304321/ IARC V100A Dichloropropane 21:52 http://www.mhlw.go.jp/stf/houdou/2r9852000002x6at.html https://www.cdc.gov/niosh/npg/npgd0534.html https://www.cdc.gov/niosh/idlh/78875.html IARC V110 Diethylstilbestrol 24:03 https://doi.org/10.1016%2FS0025-7125%2816%2932122-8 https://books.google.com/books?id=-tz4J4_hgdIC&pg=PA26 https://doi.org/10.1007%2Fs11096-005-3663-z IARC V100A Ethylene oxide 25:04 https://doi.org/10.1023%2FA%3A1024891529592 IARC V100F Formaldehyde 25:53 https://doi.org/10.1002%2F14356007.a11_619 https://wwwn.cdc.gov/TSP/MMG/MMGDetails.aspx?mmgid=216&toxid=39 https://doi.org/10.1016%2Fj.mrrev.2008.07.002 IARC V100F Lindane 28:01 http://www3.cec.org/islandora/en/item/11389-north-american-regional-action-plan-lindane-and-other-hexachlorocyclohexane-isomers-final-en.pdf https://www.atsdr.cdc.gov/toxprofiles/tp43.pdf https://www.who.int/ipcs/publications/pesticides_hazard_rev_3.pdf https://doi.org/10.1016%2FS1470-2045%2815%2900081-9 IARC V113 Methoxsalen 29:05 http://www.cancer.org/cancer/cancercauses/othercarcinogens/generalinformationaboutcarcinogens/known-and-probable-human-carcinogens IARC Vol 100A 4,4'-Methylenebis(chloroaniline) 29:48 https://www.cdc.gov/niosh/npg/npgd0411.html IARC V100F 2-Naphthylamine 30:44 https://doi.org/10.1002%2F14356007.a17_009 https://www.cdc.gov/niosh/npg/npgd0442.html IARC V100F NNN/NNK 31:23 https://doi.org/10.1093%2Fcarcin%2Fbgt162 https://doi.org/10.1073%2Fpnas.0506581102 http://nj.gov/health/eoh/rtkweb/documents/fs/2900.pdf https://doi.org/10.3892%2Fijo.29.4.745 https://doi.org/10.3390%2Fijerph120809046 IARC V100E Polychlorinated ones 33:51 https://sciencedirect.com/science/article/abs/pii/0272059088901480 https://doi.org/10.1080%2F026520300283360 https://www.epa.gov/ingredients-used-pesticide-products/pentachlorophenol IARC V100F Phenacetin 37:43 https://doi.org/10.1016%2FS0049-3848%2803%2900416-X IARC V100A Sulfur mustard 38:40 IARC V100F Toluidine 39:53 https://doi.org/10.1006%2Fabbi.1999.1461 IARC V100F Trichloroethylene 41:44 IARC V106 Vinyl chloride 42:36 IARC V100F

Use code POGCHEMISTJAN60 for 60% off your first box at https://strms.net/ThatChemistFactorDecemberYT60 #ad -------------------------------------------------------------------------------------------- In this video, I decide which PPE (Personal Protective Equipment) is the best, and which PPE is the worst. Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist Second Discord link if the first one is borked - https://discord.gg/QWNPETtPcZ

In this video, I discuss the Diels Alder reaction, including regular demand and inverse demand, the ortho/para rule, and endo/exo selectivity. I also briefly discuss molecular orbital theory. This is the 50th video in the Introductory Organic Chemistry series. playlist link - https://www.youtube.com/playlist?list=PL6OLqxmk7RtzLTsvdjQXsAO38aGuJj3e6 https://www.patreon.com/thatchemist Community Discord - https://discord.gg/thatchemist ---------------------------------------------------------------------------------------------------------------------------------- Links to articles discussed in this episode: phosphonate alkyne - https://www.doi.org/10.1016/j.tet.2011.03.076 isoindole maleimide - https://www.doi.org/10.1021/ja0658259 sulfone maleimide - https://www.doi.org/10.1021/ol201095b tetracyanoethylene - https://www.doi.org/10.1002/chem.200700796 vinyl ether inverse DA - https://www.doi.org/10.1016/j.tet.2011.03.034 dihydrofuran inverse DA - https://www.doi.org/10.1016/S0040-4020(00)00937-6 ----------------------------------------------------------------------------------------------------------------------------------

Download ReactionFlash for free using the following links: Apple App Store: https://apps.apple.com/app/apple-store/id432080813?pt=119296909&ct=ThatChemist-Ad3&mt=8 Google Play Store: https://play.google.com/store/apps/details?id=ch.reaxys.reactionflash&hl=en_GB&gl=US&utm_campaign=reactionflash&utm_source=thatchemist-ad3&utm_medium=video&utm_content=descriptionlink&utm_term=ad3 This video is sponsored by Reaxys. In this video, I discuss five important papers in organic synthesis that were published in December 2022. Make sure you share this series with other chemists in your network, especially ones who don't usually watch YouTube! Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist Backup Discord link - https://discord.gg/QWNPETtPcZ Important Papers Playlist - https://youtube.com/playlist?list=PL6OLqxmk7RtyRkdJhXK8NWpT1krGNq1p4 ----------------------------------------- References: First Paper – https://pubs.acs.org/doi/pdf/10.1021/jacs.2c11024 Second Paper – https://www.nature.com/articles/s41557-022-01087-9 Boron Chemistry Video – https://youtu.be/aFfSIQQnoq0 Background paper on metal carbenoids – https://pubs.acs.org/doi/pdf/10.1021/jacs.7b05457 Third Paper – https://pubs.acs.org/doi/pdf/10.1021/jacs.2c10570 Fourth Paper – https://pubs.acs.org/doi/pdf/10.1021/jacs.2c10856 Pinnick Oxidation Video – https://youtu.be/vCOx6XqrkQ4 Fifth Paper – https://www.science.org/doi/10.1126/science.abq1274 -------------------------------------- Honorable Mentions Pyrimidines into pyrazoles - https://pubs.acs.org/doi/pdf/10.1021/jacs.2c10746 Aminoacylation - https://pubs.acs.org/doi/pdf/10.1021/jacs.2c11209 Multicomponent annulation - https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.202210822 Difluorovinyl iodonium - https://doi.org/10.1038/s42004-022-00772-7 Thianthrenation - https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.202214096 Asymmetric acyloin - https://pubs.acs.org/doi/pdf/10.1021/jacs.2c10072 Meta functionalization - https://www.nature.com/articles/s41557-022-01101-0 Remote oxidation - https://pubs.acs.org/doi/pdf/10.1021/jacs.2c11428

Lyrics: On the twelfth day of Labwork, my research gave to me 12 stopcocks leaking 11 pipettes breaking 10 beakers spilling 9 joints a-seizing 8 test tubes smoking 7 thiols reeking 6 fingers missing 5 Golden Tars 4 acid burns 3 close calls 2 dirty gloves, and And a visit from the police A huge thank you to all of the Chemtubers who contributed! @ChemicalForce @THYZOID @Chemiolis @NurdRage @AdvancedTinkering Tom and Nigel were encouraging, but they chose to abstain from having their beautiful voices contribute to this festive season in a musical medium. Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist Second Discord link if the first one is borked - https://discord.gg/QWNPETtPcZ The way I made this song was terrible - I used a synthesizer in LMMS, and MIDI-mapped the song, then I recorded my audio in OBS, and processed everyone's audio in Adobe Audition. Once Audition corrupted the entire project, and I redid it and exported it in one go, I used Premiere to piece the video together with the audio. (I know how to use Cubase, but I don't actively do anything music-related, so no license :/).

In this video, we explore the taste of ten different sugars, and decide which sugars are sweet, and which ones taste worse than Grimace’s feet after a long day at McDonalds. If you would like to order the same scale that I have, the HRB303 (with Glass Draft Shield), you can visit www.lwmeasurements.com to see all of the great scales that they have to offer! Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist Second Discord link if the first one is borked - https://discord.gg/QWNPETtPcZ - 0:00 intro 4:33 Sucrose 8:43 Lactose 15:29 Maltose 20:19 Trehalose 24:45 Glucose 30:26 Mannose 35:17 Fructose 37:47 Psicose/Allulose 40:26 Xylose 42:53 Ribose - General Procedures General Procedure 1. Preparation of Standard Citric Acid Solution Citric acid (2.007 g, 10.4 mmol) was placed in a large beaker (500 mL) and pre-boiled, room-temperature tap water (~500 mL) was added. The solution was mechanically stirred (using a polystyrene spoon) until homogeneous. The resulting citric acid solution was covered and stored at room temperature prior to its use. General Procedure 2. Preparation of Aqueous ‘Citric Acid-ade’ The sugar (e.g. lactose) was added in one portion to a small polystyrene vessel (60 mL). This was then suspended in the standard citric acid solution (~25 mL) with the aid of mechanical stirring from a translucent mouth-pipette (straw; material not determined). The resulting suspension or solution was mouth-pipetted in several small portions for the large mammal assay. Methods and Materials All chemicals used in this video were food grade. The chemicals were obtained from Amazon Canada (in the cases of lactose, glucose, psicose/allulose, and ribose), Ebay (in the case of maltose and xylose), Bulk Barn (citric acid), Bulk Supplements (in the case of trehalose, mannose, and fructose) and Save On Foods (sucrose). The itemized prices that I paid do not include the cost of shipping or taxes. The combined cost of shipping was $56.00 CDN + $48.01 USD. *Warning* consuming large amounts of sugars that your body isn’t accustomed to may result in gastric discomfort for you, and nausea for people in your proximity. If you are introducing new sugars into your diet, try eating a small amount before introducing larger amounts into your diet. Take up any concerns with a medical doctor, which I am not. Links to Vendors for Each Sugar Sucrose – Save on Foods, but the brand is Rogers Citric Acid – I got it at a Bulk Barn, but the brand is LorAnn Oils Lactose – https://www.amazon.ca/gp/product/B09ZTRJ3YB (I paid $15.95 CDN for 100 g) Maltose – https://www.ebay.ca/itm/154364495277 (I paid $8.50 AU for 50 g) Trehalose – https://www.bulksupplements.com/products/trehalose-powder (I paid $11.96 USD for 100 g) Glucose – https://www.amazon.ca/gp/product/B09ZTNYK7F (I paid $12.95 CDN for 100 g) Mannose – https://www.bulksupplements.com/products/d-mannose (I paid $16.96 USD for 100 g) Fructose – https://www.bulksupplements.com/products/fructose-powder (I paid $9.96 USD for 100 g) Psicose/Allulose – https://www.amazon.ca/Health-Garden-Allulose-Sweetener-14/dp/B07DD58PNJ (I paid $35.24 CDN for 397 g) Xylose – https://www.ebay.ca/itm/282126747479 (I paid $5.50 USD for 454 g) Ribose – https://www.amazon.ca/gp/product/B078WVR8GR (I paid $23.99 CDN for 113 g) Molecules in this tierlist – sucrose, lactose, maltose, trehalose, glucose, mannose, fructose, alluose/psicose, xylose, ribose. References Amino Acid Tierlist - https://youtu.be/edSaOl08Cqs Glycan polymer streptococcus mutans - https://rb.gy/0z5qtk glycemic index for sucrose - https://rb.gy/uir3nq Lactase deficiency - https://rb.gy/7byevy Lactose is less sweet than galactose/glucose - https://rb.gy/xvp08d maltose malt - https://rb.gy/w3qize 4 enzymes break down maltose - https://rb.gy/cumja0 Maltose Glycemic Index - https://draxe.com/nutrition/maltose/ Trehalose freezing tolerance - https://rb.gy/xdd5mp Trehalose intolerance - https://rb.gy/gygimf Sperm storage using trehalose - https://rb.gy/aicx8e Glucose discovery - https://rb.gy/fl4ae3 Mannose UTIs (for) - https://rb.gy/fu276a Mannose UTIs (against) - https://rb.gy/gnrlnt Fructose obesity - https://rb.gy/to0tya Psicose corn 2017 - https://rb.gy/ozvrdc Psicose Glycemic Index - https://rb.gy/rsx3xh Xylose kidneys - https://rb.gy/2w3c3q Weighing out sugars (second channel) - https://youtu.be/w2277uMrwSg Ribose congestive heart failure - https://rb.gy/wbddda Chronic fatigue ribose - https://rb.gy/wgvoyc Ribose Insulin negative glycemic index - https://rb.gy/i4pjnq Masses Citric Acid (anhydrous) 2.007 g (10.5 mmol) Sucrose 3.041 g (8.88 mmol) Lactose 8.370 g (24.3 mmol) Maltose 6.620 g (19.3 mmol) Trehalose 6.671 g (19.5 mmol) Glucose 4.011 g (22.3 mmol) Mannose 4.901 g (27.2 mmol) Fructose 2.631 g (14.6 mmol) Allulose 4.465 g (24.8 mmol) Xylose 4.908 g (32.7 mmol) Ribose 3.169 g (21.1 mmol)

Here are the viewer-suggested highlights for the past year! Thank you for being amazing viewers, and mouthpipetting every single day. I also want to thank the people from Spicy who contributed FOOMPS for the end of the video! Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist Second Discord link if the first one is borked - https://discord.gg/QWNPETtPcZ 0:00 – intro 0:10 – Toxic WJPR 0:32 – Rat chlorination 2:06 – cringe tierlist 2:20 – seriously stupid chlorine lasers 2:50 – deoxofluor 3:49 – Ex&F tierlist 4:00 – amino acid tierlist 7:30 – age restricted tierlist 8:07 – vaped smoke detector chempilation 10:13 – nuclear comments/chempit 10:58 – propofol incapacitating agent tierlist 12:59 – hair chemistry 13:53 – carrot chemistry 14:16 – cursed tierlist part 2 – fluoronium 15:08 – agrochemicals tierlist 15:33 – cursed molecules tierlist 15:40 - cursed tierlist part 2 – outro 15:44 – outro 15:57 - FOOMPS ---------------------------------------------------------------------------------------------------------------------------------- Videos referenced in order Toxic WJPR - https://youtu.be/7YoCsLhbU0g Rat chlorination - https://youtu.be/m2BI-FVl6fc Cringe tierlist - https://youtu.be/OxZ1XShZt58 Seriously stupid chlorine lasers - https://youtu.be/x75A6vGrPuI Deoxofluor - https://youtu.be/Psc6MgWMajk Ex&F tierlist - https://youtu.be/Im5Y0ogGr0I Amino acid tierlist - https://youtu.be/edSaOl08Cqs Age restricted tierlist - https://youtu.be/u6wYwgGqGs8 Vaped smoke detector chempilation - https://youtu.be/14UggnpN39w Nuclear comments/chempit - https://youtu.be/_iLOd9fPkXo Propofol incapacitating agent tierlist - https://youtu.be/T9stdKOB22I Hair chemistry - https://youtu.be/NCCl66O8BRw Carrot chemistry - https://youtu.be/wkES6aHpWXk Cursed tierlist part 2/fluoronium - https://youtu.be/7mCL-C13ZGw Agrochemicals tierlist - https://youtu.be/6WfevwtLi44 Cursed molecules tierlist - https://youtu.be/ofLuq4Tyeus ----------------------------------------------------------------------------------------------------------------------------------

Download ReactionFlash for free using the following links: Apple App Store: https://apps.apple.com/app/apple-store/id432080813?pt=119296909&ct=ThatChemist-Ad2&mt=8 Google Play Store: https://play.google.com/store/apps/details?id=ch.reaxys.reactionflash&hl=en_GB&gl=US&utm_campaign=reactionflash&utm_source=thatchemist-ad2&utm_medium=video&utm_content=descriptionlink&utm_term=ad2 This video is sponsored by Reaxys. In this video, I discuss five important papers in organic synthesis that were published in November 2022. Make sure you share this series with other chemists in your network, especially ones who don't usually watch YouTube! Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist Backup Discord link - https://discord.gg/QWNPETtPcZ Important Papers Playlist - https://youtube.com/playlist?list=PL6OLqxmk7RtyRkdJhXK8NWpT1krGNq1p4 ----------------------------------------- References: First Paper – https://pubs.acs.org/doi/pdf/10.1021/acscatal.2c04010 Second Paper – https://pubs.acs.org/doi/pdf/10.1021/jacs.2c09244 Third Paper – https://pubs.acs.org/doi/pdf/10.1021/jacs.2c08989 Fourth Paper – https://www.science.org/doi/10.1126/science.ade6029 Fifth Paper – https://pubs.acs.org/doi/pdf/10.1021/acs.orglett.2c03570 -------------------------------------- Papers I was an author on in the past month: https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/chem.202202862 https://pubs.acs.org/doi/10.1021/acs.orglett.2c03540 -------------------------------------- Honorable Mentions 3-Halogenation of pyridines - https://doi.org/10.1126/science.add8980 Cyclopropane pyridines - https://doi.org/10.1002/anie.202214507 R-F organocuprates - https://doi.org/10.1021/acs.orglett.2c03775 1,2,3-Triazenes - https://doi.org/10.1021/acs.joc.2c02082 Benzoylformates - https://doi.org/10.1021/jacs.2c09248 Decatungstate acetylation - https://doi.org/10.1021/acs.orglett.2c03142 Decatungstate epimerization - https://doi.org/10.1126/science.add6852 Sulfoxonium Ylides - https://doi.org/10.1038/s41467-022-34401-7 Bicyclo[3.1.1]heptanes - https://doi.org/10.1021/jacs.2c09733

Back by popular demand, we have another cursed molecules tierlist! First Cursed Tierlist - https://www.youtube.com/watch?v=ofLuq4Tyeus Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist Second Discord link if the first one is borked - https://discord.gg/QWNPETtPcZ ---------------------------------------------------------------------------------------------------------------------------------- References: Thiarubrine B - https://pubs.acs.org/doi/10.1021/ja00099a097 HIV - https://doi.org/10.1111/j.1751-1097.1993.tb02936.x Cicutoxin - https://doi.org/10.1080/15563650902904332 https://doi.org/10.1002%2Fejoc.200801172 Hoye’s Witchcraft - https://doi.org/10.1021/acs.orglett.8b02473 Hypoglycin - https://doi.org/10.1016%2Fb978-0-12-801227-7.00004-4 Varacin - https://doi.org/10.1021/ja016495p Dicyanoacetylene - https://doi.org/10.1021%2Fja01590a075 Titan - https://doi.org/10.1016%2FS0032-0633%2897%2900088-3 Syntin - https://web.archive.org/web/20090920132913/http://www.novosti-kosmonavtiki.ru/nk/forum-pic/Omar_NK2008-02.pdf Diazodinitrophenol - http://babel.hathitrust.org/cgi/pt?id=njp.32101044011037;view=1up;seq=541 Cymoxanil - https://pubchem.ncbi.nlm.nih.gov/compound/Cymoxanil Thiamethoxam - https://doi.org/10.1002%2Fps.365 Huperzine A - https://doi.org/10.1016%2FS0091-3057%2803%2900111-4 Pentaphenylpentaphospholane - https://youtu.be/uusXv4DhANw Batrachotoxin - https://doi.org/10.1007%2FBF02152303 Orysastrobin - https://pubs.acs.org/doi/10.1021/jf202228p Divinyl ether - https://csahq.org/docs/default-source/news-and-events-docs/csa-bulletin-docs/winter-2007/guedel_064.pdf?sfvrsn=60e3c646_2 Bixin - https://doi.org/10.1126%2Fscience.1085162 Toxoflavin - https://pubmed.ncbi.nlm.nih.gov/24542943/ C01-A042 - https://youtu.be/5IFsaBBav78 Guanitoxin - https://doi.org/10.1021%2Fja00202a057 Perfluorocubane - https://youtu.be/Tn9EANWD96s Rocuronium bromide - https://doi.org/10.1002%2F14651858.CD002788.pub3 Melarsoprol - https://www.who.int/mediacentre/factsheets/fs259/en/ Ethchlorvynol - https://patents.google.com/patent/US2746900A/en Lectka’s Illegal Fluoronium - https://www.nature.com/articles/s41467-021-25592-6 1,4,7-Trimethyloxatriquinane - https://pubs.acs.org/doi/10.1021/ja103880c ----------------------------------------------------------------------------------------------------------------------- Molecules for this tierlist - Thiarubrine B, Cicutoxin, Hoye’s Witchcraft, Hypoglycin, Varacin, Dicyanoacetylene, Syntin, Diazodinitrophenol, Cymoxanil, Thiamethoxam, Huperzine A, Pentaphenylpentaphospholane, Batrachotoxin, Orysastrobin, Divinyl ether, Bixin, Toxoflavin, C01-A042, Guanitoxin, Perfluorocubane, Rocuronium bromide, Melarsoprol, Ethchlorvynol, Lectka’s Illegal Fluoronium, 1,4,7-Trimethyloxatriquinane Tierlist Playlist - https://www.youtube.com/playlist?list=PL6OLqxmk7Rtx7YVG6hOgVHAgisH-y8yIW ------------------------------------------------------------------------------------- Music (in order; Title - Artist): Six Seasons - Unicorn Heads Bonfire - An Jone Friendly Dance - Nico Staf Press Fuse - French Fuse Target Fuse - French Fuse Duh Fuse - French Fuse Target Fuse - French Fuse

If you practice chemistry - make sure you use protection (PPE). This is the 29th chempilation Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist Second Discord link if the first one is borked - https://discord.gg/QWNPETtPcZ Incapacitating Agent Tierlist - https://youtu.be/T9stdKOB22I Channel Update Video (on the 2nd Channel) - https://youtu.be/eoM-RCIMB3E Chempilation Playlist - https://www.youtube.com/playlist?list=PL6OLqxmk7Rtx_0L7pPT5tzLD7rT-93riO -------------------------------------- Music (title - artist): Six Seasons - Unicorn Heads Walking in the Sky - Nico Staf Dulce Reggaeton - An Jone

This time, we're ranking the abbreviations for chemicals! some chemicals have based abbreviations, while other chemicals have cursed ones. Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist Second Discord link if the first one is borked - https://discord.gg/QWNPETtPcZ ---------------------------------------------------------------------------------------------------------------------------------- References: NBA eEROS - https://doi.org/10.1002/047084289X.rb268.pub2 FAP paper - https://doi.org/10.1016/j.jfluchem.2005.04.017 ---------------------------------------------------------------------------------------------------------------------------------- Molecules for this tierlist - BOC – tert-butoxycarbonyl, TIPS-Cl – Triisopropylsilyl chloride, MOM-Cl – Methoxymethyl chloride, CAMP – Cyclic adenosine monophosphate, TPAP – Tetrapropylammonium perruthenate, FOOF – Dioxygen difluoride, DABCO – 1,4-diazabicyclo[2.2.2]octane, DEADCAT – Diethyl azodicarboxylate, Cp* - Pentamethylcyclopentadienyl, BArF – Tetrakis(3,5-bis(trifluoromethyl)phenyl)borate, DiPT – Diisopropyltryptamine, DOTA - 2,2′,2′′,2′′′-(1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetrayl)tetraacetic acid, CAM – Ceric ammonium molybdate, PPi – inorganic pyrophosphate, TEA – Triethylamine, BCNU – 1,3-Bis(2-chloroethyl)-1-nitrosourea, BAIB / PIDA – Bis(acetoxy)iodobenzene / phenyliodine(III) diacetate, NBA – N-Bromoacetamide, CAN – ceric ammonium nitrate, dUMP – Deoxyuridine monophosphate, FAP – tris(perfluoroalkyl)trifluorophosphate, DAMN – Diaminomaleonitrile, SEX – Sodium ethyl xanthate. Tierlist Playlist - https://www.youtube.com/playlist?list=PL6OLqxmk7Rtx7YVG6hOgVHAgisH-y8yIW ------------ Music (in order; Title - Artist): Tropic Fuse - French Fuse India Fuse - French Fuse Positive Fuse - French Fuse Duh Fuse - French Fuse Press Fuse - French Fuse Target Fuse - French Fuse I Feel It All So Deeply - Bail Bonds Rinse Repeat - DivKid

This time, we're ranking incapacitating agents! The term incapacitating agent is defined by the United States Department of Defense as: "An agent that produces temporary physiological or mental effects, or both, which will render individuals incapable of concerted effort in the performance of their assigned duties." It describes an agent which renders a person unable to harm themselves or others, regardless of consciousness. Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist Second Discord link if the first one is borked - https://discord.gg/QWNPETtPcZ ---------------------------------------------------------------------------------------------------------------------------------- References: CS Gas Chempilation - https://youtu.be/9a7a11i9Ce4 WKUK PCP - https://www.youtube.com/watch?v=tFUvmZWf4hI Hamilton's Pharmacopeia PCP - https://www.vicetv.com/en_us/video/a-positive-pcp-story/580fbc1befcfab397fd8c8b5 Scary book - Jared Ledgard, A Laboratory History of Chemical Warfare Agents - ISBN-13 number 978-0615136455 Nerve Agent Tierlist - https://www.youtube.com/watch?v=5IFsaBBav78 ---------------------------------------------------------------------------------------------------------------------------------- Molecules for this tierlist - Agent 15 (BZ), DMHP (EA-2233), Nonivamide, GHB, Phenacyl chloride (CN/Mace), Chloroform, Xylyl bromide, Capsaicin (OC), CS gas (EA-1779), MPK (EA-1778), Ethanol, Sneeze Mace, CR gas (EA-3547), LSD (EA-1729), Halothane, Adamsite (DM), Chloral hydrate, Carfentanil, Rohypnol (roofies), Sodium thiopental, PCP (EA-2148), Ketamine, Fentanyl, Nitrous oxide, Propafol, Chloroacetone, Diimine (DIM), Bromobenzyl cyanide (BBC), Chloropicrin (PS) Tierlist Playlist - https://www.youtube.com/playlist?list=PL6OLqxmk7Rtx7YVG6hOgVHAgisH-y8yIW

Amino acids are great, but do they taste great? In this video, I taste 20 of the 21 amino acids (sorry selenocysteine), as well as monosodium glutamate. I also rank them individually, as well as on McDonalds fries! A huge thanks to ImKibitz and NileRed for their feedback on the video! Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist Second Discord link if the first one is borked - https://discord.gg/QWNPETtPcZ ---------------------------------------------------------------------------------------------------------------------------------- References: Tom’s Salt Video - https://www.youtube.com/watch?v=RJh9yTIBY48 Amino Acid Vendor (not a sponsor)- https://www.the-odin.com/amino-acid-tasting-and-cooking-set-for-molecular-gastronomy/ Tom’s Nitrated McDonalds - https://www.youtube.com/watch?v=M2YbK7FnESU Tom S4N4 Grudge Video - https://www.youtube.com/watch?v=I-ZawsbYpmo Fruit Tierlist - https://www.youtube.com/watch?v=NBB1COKd4VQ ---------------------------------------------------------------------------------------------------------------------------------- Molecules for this tierlist - Arginine, histidine, glutamic acid, methionine, alanine, lysine, threonine, tyrosine, valine, glycine, cysteine, asparagine, aspartic acid, tryptophan, monosodium glutamate, leucine, glutamine, serine, phenylalanine, isoleucine, proline. Tierlist Playlist - https://www.youtube.com/playlist?list=PL6OLqxmk7Rtx7YVG6hOgVHAgisH-y8yIW

Download ReactionFlash for free using the following links: Apple App Store: https://apps.apple.com/app/apple-store/id432080813?pt=119296909&ct=ThatChemist-Ad1&mt=8 Google Play Store: https://play.google.com/store/apps/details?id=ch.reaxys.reactionflash&hl=en_GB&gl=US&utm_campaign=reactionflash&utm_source=thatchemist-ad1&utm_medium=video&utm_content=descriptionlink&utm_term=ad1 This video is sponsored by Reaxys. In this video, I discuss five important papers in organic synthesis that were published in October 2022. Make sure you share this series with other chemists in your network, especially ones who don't usually watch YouTube! Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist Backup Discord link - https://discord.gg/QWNPETtPcZ Important Papers Playlist - https://youtube.com/playlist?list=PL6OLqxmk7RtyRkdJhXK8NWpT1krGNq1p4 ---------------------------------------------------------------------------------------------------------------------------------- Links to articles discussed in this episode: First paper – https://doi.org/10.1021/acs.joc.2c02000 Second paper – https://doi.org/10.1038/s41557-022-01027-7 Third paper – https://doi.org/10.1038/s41467-022-33827-3 Fourth paper – https://doi.org/10.1021/jacs.2c10010 Fifth paper – https://doi.org/10.1021/jacs.2c08244 B(4)−H Amination of o Carboranes - https://doi.org/10.1021/acs.orglett.2c02590 Aryl Azides to Aminopyridines - https://doi.org/10.1021/jacs.2c08464 Azetidine-Based Energetics - https://doi.org/10.1021/jacs.2c08191 Arylation of Iodocarboranes - https://doi.org/10.1021/acs.orglett.2c02648 Esters from Aryl Bromides - https://doi.org/10.1021/acs.orglett.2c03034 Photochemical Hydrosilylation of Alkenes - https://doi.org/10.1021/acs.joc.2c01885 Synthesis of Gedunin - https://doi.org/10.1021/jacs.2c09048 Pyrimidines and Quinazolines from Pyrazoles/Indazoles - https://doi.org/10.1021/jacs.2c09616 Vinyl Sulfides from Sulfoniums - https://doi.org/10.1021/acs.orglett.2c03095 Masked Aldehyde Radical Conjugate Addition - https://doi.org/10.1021/acscatal.2c03229 Enantioselective Dearomative Cyclization - https://doi.org/10.1002/anie.202207518 Ortho C-H Hydroxylation - https://doi.org/10.1021/jacs.2c08332 Boronic Ester [2+2] Cycloadditions and Total Syntheses - https://doi.org/10.1021/jacs.2c08777 ----------------------------------------------------------------------------------------------------------------------------------

Which chemicals carry the greatest risks? In this episode I discuss some compounds with the highest possible NFPA ratings, and we determine which ones are the most risky! Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist Second Discord link if the first one is borked - https://discord.gg/QWNPETtPcZ Speaking of risky, I have to say that molotay is remarkable. ---------------------------------------------------------------------------------------------------------------------------------- References: Graduated Cylinder History Video - https://youtu.be/5TTu5Fx9T78 Hamilton Morris Podcast Episode - https://www.patreon.com/posts/73789212 Methylhydrazine Mycotoxin Video - https://www.youtube.com/watch?v=pkHTzVRVOp0 nBuLi Titration - https://doi.org/10.1016/S0022-328X(97)00143-5 Ether Peroxide Video - https://www.youtube.com/watch?v=D8tktdPSIso NileRed Magnesium Silicide - https://www.youtube.com/watch?v=KXCBnznxxIk ---------------------------------------------------------------------------------------------------------------------------------- Molecules for this tierlist - tert-Butyl hydroperoxide, cyanogen, propargyl bromide, arsine, monomethylhydrazine, diazomethane, nickel tetracarbonyl, hydrogen cyanide, tert-butyllithium, acetaldehyde, trimethylaluminum, acrylonitrile, stibine, triethylaluminum, buli, butadiene, germane, ethylene oxide, TFE, trichlorosilane, pentaborane(9), diethyl ether hydroperoxide, dichlorosilane, vinyl chloride, diborane, picric acid, diethylaluminum chloride, silane Tierlist Playlist - https://www.youtube.com/playlist?list=PL6OLqxmk7Rtx7YVG6hOgVHAgisH-y8yIW

Nerve agents are completely terrifying - in this episode I discuss the different classes of nerve agents, and we determine which ones are the most EVIL. Exposure to nerve agents is usually treated with atropine and pralidoxime chloride (2-PAM chloride). Nerve agents inhibit acetylcholinesterase, which is an enzyme that catalyzes the breakdown of acetylcholine. Some nerve agents covalently bind to the enzyme, and can damage the active site of the enzyme, so the acetylcholine builds up, the signal keeps sending, and the motor neurons keep firing. The G series and V series of nerve agents were mass produced, weaponized agents, while the EA series, A series, and others are not known to be mass produced or weaponized. Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist Second Discord link if the first one is borked - https://discord.gg/QWNPETtPcZ ---------------------------------------------------------------------------------------------------------------------------------- References: (Graphic) Rabbits exposed to nerve agents - https://www.youtube.com/watch?v=1J9rUdJ9HLM Scary book - Jared Ledgard, A Laboratory History of Chemical Warfare Agents - (the link to this book was deactivated; perhaps the uploader had violated the hosting site's TOS - its ISBN-13 number is‎ 978-0615136455) Methyl cyclosarin treatment patent - https://patents.google.com/patent/US10124043 Earliest Methyl cyclosarin reference - https://sci-hub.se/10.1007/BF00354767 Previous Tierlist - https://www.youtube.com/watch?v=xgjJBJdPCKw Hydrolysis of VX/EA-2192 - https://doi.org/10.1289/ehp.99107933 VR 'first Novichok' - https://cen.acs.org/articles/96/i12/Nerve-agent-attack-on-spy-used-Novichok-poison.html SL-599 (SB-8) paper - https://pubs.acs.org/doi/10.1021/ja01846a078 Perfect 10 patent - https://patents.google.com/patent/US4686293 ---------------------------------------------------------------------------------------------------------------------------------- Molecules for this tierlist - Tabun (GA), Sarin (GB), Chlorosarin, Thiosarin (GBS), Soman (GD), Cyclosarin (GF), Methyl cyclosarin (EA-1356), VX, EA-2192, Russian VX (VR), Chinese VX, V-sub x, A-230, A-234, A-242, C01-A039, C01-A042, Neostigmine, TMTFA, TL-599 (SB-8), T-1123, T-1152, 4-692-530-01, 4-686-293-01 (Agent 1-10), 4-686-293-02 (Agent 1-8) Tierlist Playlist - https://www.youtube.com/playlist?list=PL6OLqxmk7Rtx7YVG6hOgVHAgisH-y8yIW

Academic publishers should really do better than this... Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist Second Discord link if the first one is borked - https://discord.gg/QWNPETtPcZ ---------------------------------------------------------------------------------------------------------------------------------- Links to articles discussed in this episode: https://pubs.acs.org/doi/10.1021/jacs.2c09578 ----------------------------------------------------------------------------------------------------------------------------------

Only generate toxic gasses in a well-ventilated area - do not breathe the spicy air. This is the 28th chempilation Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist Second Discord link if the first one is borked - https://discord.gg/QWNPETtPcZ Mark Rober Pool Pee video - https://www.youtube.com/watch?v=S32y9aYEzzo My nitration video - https://www.youtube.com/shorts/7z4mpa2zfn4 Chempilation Playlist - https://www.youtube.com/playlist?list=PL6OLqxmk7Rtx_0L7pPT5tzLD7rT-93riO

This is a completely educational video about chemicals - there is nothing special to see here. 👼 Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist Second Discord link if the first one is borked - https://discord.gg/QWNPETtPcZ @NileRed video - https://www.youtube.com/watch?v=LL3kVtc-4vY Molecules for this tierlist - Fukinone, Amyl nitrite, Bongkrek acid, Polonium monoxide, Bromo-dragonfly, VX, Assoanine, Hydrogen cyanide, Moronic acid, Cucurbituril, Sarin, TNT, Propylhexedrine, Nitrous oxide, Arecoline, Cocaine, Bromic acid, Sodium oxybate, Rhamnetin, Mysterious nitrostyrene, THC, GBL, Warfarin, Hyperectine, Amygdalin, Dihydrogen monoxide, 3,3-diethylpentane, Homoeriodictyol, Rishitin, Atrazine Tierlist Playlist - https://www.youtube.com/playlist?list=PL6OLqxmk7Rtx7YVG6hOgVHAgisH-y8yIW The video was demonetized for a brief period of time - it turns out the algorithm didn't know what 'Fukinone' was :)

Please do not collect samples of radium or other radioactive elements, and if you do, please tell your roommates... This is the 27th chempilation Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist Second Discord link if the first one is borked - https://discord.gg/QWNPETtPcZ

In this week's chemistry tierlist, we continue ranking the elements - this time we cover elements 21-40. Fruit Tierlist video on the second channel - https://youtu.be/NBB1COKd4VQ Join the Community Discord! - https://discord.gg/thatchemist Second Discord link if the first one is borked - https://discord.gg/QWNPETtPcZ ---------------------------------------------------------------------------------------------------------------------------------- Links to stuff discussed in this episode: YInMn Blue - https://www.youtube.com/watch?v=NxbOQ1FhqdQ Paris Green Thyzoid - https://www.youtube.com/watch?v=KJZdCqRwBFM ---------------------------------------------------------------------------------------------------------------------------------- Watch more tierlists - https://www.youtube.com/playlist?list=PL6OLqxmk7Rtx7YVG6hOgVHAgisH-y8yIW

Did Einstein really do it, and was it a graduated cylinder or a burette? Fruit Tierlist (second channel) - https://youtu.be/NBB1COKd4VQ Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist Second Discord link if the first one is borked - https://discord.gg/QWNPETtPcZ ---------------------------------------------------------------------------------------------------------------------------------- References Grad Cylinder Einstein - https://www.sluiceartfair.com/2019/contributing/when-was-graduated-cylinder-invented/ Mohr’s Book (Lehrbuch der chemisch-analytischen Titrirmethode) - https://play.google.com/books/reader?id=oLjnAAAAMAAJ&pg=GBS.PA116&hl=en Gay-Lussac Review – https://doi.org/10.1016/0039-9140(78)80162-3 Laboratory instrumentation in clinical biochemistry: an historical perspective (source for several people in this video)- https://doi.org/10.1177/014107689709001013 Site pointing to Descroizilles - http://diyhpl.us/~bryan/irc/labautopedia-history-of-automated-liquid-handling.html Descroizilles as the ‘Inventor’ - https://doi.org/10.1021/ed028p508 Descroizilles as the ‘father’ - https://core.ac.uk/download/pdf/200977142.pdf (François-Antoine-Henri Descroizilles (1781-1825), démonstrateur royal de chimie, apothecary, inventor and industrial chemist: the father of titrimetric analysis. Part I) Comprehensive summary of volumetric analysis (source for several people in this video) – https://doi.org/10.1016/b978-0-08-010980-0.50011-0 ----------------------------------------------------------------------------------------------------------------------------------

The Nobel Prize in Chemistry for 2022 has been awarded to Barry Sharpless, Morten Meldal, and Carolyn Bertozzi for their contributions to Click-Chemistry and Bioorthogonal Chemistry. Click chemistry gets its name from the fact that both reagents essentially 'click' together! Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist Second Discord link if the first one is borked - https://discord.gg/QWNPETtPcZ #nobelprize #nobelprize2022 #nobelprizewinners

In this week's chemistry tierlist, we discuss some of the most annoying names for chemicals - what were we thinking... Hey 🍎! What? 🗡 Join the Community Discord! - https://discord.gg/thatchemist Second Discord link if the first one is borked - https://discord.gg/QWNPETtPcZ ---------------------------------------------------------------------------------------------------------------------------------- Links to stuff discussed in this episode: Gravol video - https://youtu.be/hhpRAbsjpLM ---------------------------------------------------------------------------------------------------------------------------------- Watch more tierlists - https://www.youtube.com/playlist?list=PL6OLqxmk7Rtx7YVG6hOgVHAgisH-y8yIW

There is a new patreon exclusive video! Support the Channel on Patreon - https://www.patreon.com/thatchemist This is the 26th chempilation. Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist Second Discord link if the first one is borked - https://discord.gg/QWNPETtPcZ

In this week's chemistry tierlist, we do the unspeakable - judge the elements. This entire series was inspired from Tom's video ranking all of the elements on the periodic table - https://www.youtube.com/watch?v=qIvJ9LA8Ib8 Join the Community Discord! - https://discord.gg/thatchemist Second Discord link if the first one is borked - https://discord.gg/QWNPETtPcZ ---------------------------------------------------------------------------------------------------------------------------------- Links to stuff discussed in this episode: Calcium Acetate Video - https://youtu.be/T6Xnc_F_DrM Periodic Videos Mg + N2 - https://www.youtube.com/watch?v=LclOOAT6pvA ---------------------------------------------------------------------------------------------------------------------------------- Watch more tierlists - https://www.youtube.com/playlist?list=PL6OLqxmk7Rtx7YVG6hOgVHAgisH-y8yIW

Make sure you share this series with your colleagues! In this video, I discuss five important papers in organic synthesis that were published in September 2022. Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist Backup Discord link - https://discord.gg/QWNPETtPcZ ---------------------------------------------------------------------------------------------------------------------------------- Links to articles discussed in this episode: First Paper - https://www.doi.org/10.1038/s41586-022-05211-0 Second Paper - https://www.doi.org/10.1021/jacs.2c06584 Third Paper- https://www.doi.org/10.1126/science.add1383 Fourth Paper - https://www.doi.org/10.1021/jacs.2c03618 Fifth Paper - https://www.doi.org/10.1021/jacs.2c08006 Sixth Paper - https://www.doi.org/10.1038/s41557-022-01034-8 Hydroamination of Alkenes - https://www.doi.org/10.1021/jacs.2c07643 Phenols from Benzoic Acids - https://www.doi.org/10.1021/jacs.2c07529 Synthesis of the Monomeric Unit of Lomaiviticin A - https://www.doi.org/10.1021/jacs.2c07631 Umpolung N-Aryl Amide Synthesis - https://www.doi.org/10.1021/jacs.2c05986 Cyclopropenium Cation Synthesis - https://www.doi.org/10.1021/jacs.2c07769 Diastereoselective Spiropentane Synthesis - https://www.doi.org/10.1021/jacs.2c07370 Total Synth of Calyciphylline Alkaloids - https://www.doi.org/10.1021/jacs.2c05957 Grignards as Halide Nucleophiles - https://www.doi.org/10.1021/acs.joc.2c01590 Total Synth of Securinine Alkaloids - https://www.doi.org/10.1038/s41467-022-32902-z ----------------------------------------------------------------------------------------------------------------------------------

In this video, I discuss the Novec solvents as well as the flurane anesthetics, which tend to be hydrofluoroethers. This video is also the 50k subscriber special - thanks for your support! Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist Second Discord link if the first one is borked - https://discord.gg/QWNPETtPcZ ---------------------------------------------------------------------------------------------------------------------------------- Links to stuff discussed in this episode: Red Nigel video - https://www.youtube.com/watch?v=MpApxmvcd3M Novec-cooled computer - https://www.youtube.com/watch?v=YyKIZPuepl8 Novec fire suppression system - https://www.youtube.com/watch?v=aHzErSacOLY Novec 7100 ACIE paper - https://www.doi.org/10.1002/anie.201410639 My paper - https://www.doi.org/10.1021/acs.orglett.0c00099 Mayr's N parameters - https://www.cup.lmu.de/oc/mayr/reaktionsdatenbank2/ Methoxyflurane - https://www.doi.org/10.1097/00000542-200610000-00031 Methoxyflurane review - https://pubmed.ncbi.nlm.nih.gov/33927440/ Further Reading: Methoxyflurane demethylation - https://doi.org/10.1097/00000542-200610000-00019 ----------------------------------------------------------------------------------------------------------------------------------

In this AMAZING chemistry tierlist, we discuss some of the spiciest molecules with... noteworthy reputations *NOTE* I was incorrect about the fentanyl skin contact thing, apparently that is a myth! Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist Second Discord link if the first one is borked - https://discord.gg/QWNPETtPcZ ---------------------------------------------------------------------------------------------------------------------------------- Links to stuff discussed in this episode: thioacetone - https://www.youtube.com/watch?v=E_wboFJZBTU ClF3 channel - https://www.youtube.com/user/Fluorineisgreat OG MSG sus paper - https://www.nejm.org/doi/full/10.1056/NEJM196804042781419 the first dimethyl mercury link I found on google - https://cen.acs.org/safety/lab-safety/25-years-Karen-Wetterhahn-died-dimethylmercury-poisoning/100/i21 DDT limrick source (periodic videos) - https://www.youtube.com/watch?v=L3QkJ9-Wnk4 ----------------------------------------------------------------------------------------------------------------------------------

In this video, I review a recent video from The Action Lab called "Why Does This Powder Only Dissolve In Cold Water?" James makes several mistakes throughout his video, and I address them one by one. Link to the video in question - https://www.youtube.com/watch?v=tjNBmio-ll0 ---------------------------------------------------------------------------------------------------------------------------------- Links to people’s channels: Chemiolis - https://www.youtube.com/c/Chemiolis Thy Labs - https://www.youtube.com/c/THYZOIDLABORATORIES Styrene from polystyrene - https://www.youtube.com/watch?v=KXWPxOCDrSo Advanced Tinkering - https://www.youtube.com/c/AdvancedTinkering Cesium synthesis video - https://www.youtube.com/watch?v=XpCU0SyYGAA&feature=youtu.be Cesium synthesis playlist - https://www.youtube.com/playlist?list=PLLERbxERv6_9Q71ruVQsF1KMmMFUERcs2 Cody’s Lab - https://www.youtube.com/user/theCodyReeder Cesium Syntheses - https://www.youtube.com/watch?v=rSJGwnERIVU https://www.youtube.com/watch?v=tuEj5EhqcsQ ---------------------------------------------------------------------------------------------------------------------------------- Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist Second Discord link if the first one is borked - https://discord.gg/QWNPETtPcZ ---------------------------------------------------------------------------------------------------------------------------------- References: Original Paper from Henry - https://royalsocietypublishing.org/doi/pdf/10.1098/rstl.1803.0004 Calcium Acetate Hydrates - https://pubs.acs.org/doi/10.1021/je60012a040 - https://www.doi.org/ Solubility of gases in water - https://www.engineeringtoolbox.com/gases-solubility-water-d_1148.html NaOH hydrates - https://doi.org/10.1039/CT8936300890 ---------------------------------------------------------------------------------------------------------------------------------- A huge thanks to all of the creators and scientists who looked over the initial drafts of this video, including Chemiolis, Thy Labs, ImKibitz, and all of the amazing people in the That Chemist Discord!

The Column is a free email newsletter about how companies make chemicals at a global scale. You can get started for free by visiting https://thecolumn.co/?utm_source=tc002 This is the 25nd chempilation. Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist Second Discord link if the first one is borked - https://discord.gg/QWNPETtPcZ I made the thumbnail with DALL-E

Welcome back to another episode about chemistry lab mishaps! This is the 24nd chempilation. Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist Second Discord link if the first one is borked - https://discord.gg/QWNPETtPcZ I made the thumbnail with DALL-E

In this video, I answer 27 questions in this special Q&A video! Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist Second Discord link if the first one is borked - https://discord.gg/QWNPETtPcZ Thanks to Trevor for the old footage of me in a silver smock!

In this tierlist, I rank several of the common reactions taught in introductory organic chemistry! Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist Second Discord link if the first one is borked - https://discord.gg/QWNPETtPcZ

Practice Safe Synthesis. Some more terrifying stories about lab safety violations! This is the 23nd chempilation. Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist Second Discord link if the first one is borked - https://discord.gg/QWNPETtPcZ I made the thumbnail with DALL-E

Some more amazing stories from you magnificent people! This is the 22nd chempilation. Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist Second Discord link if the first one is borked - https://discord.gg/QWNPETtPcZ USCSB Sugar Video - https://youtu.be/Jg7mLSG-Yws Peroxide video - https://youtu.be/D8tktdPSIso I made this thumbnail with DOLL-E

This is an investigation into why 8-chlorotheophylline is present as a stimulant in Gravol anti-nausea medication. A huge thanks to tay and yuyuhakase from the Discord! Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist Second Discord link if the first one is borked - https://discord.gg/QWNPETtPcZ ---------------------------------------------------------------------------------------------------------------------------------- References: 1st patent - https://patents.google.com/patent/US2421714A/en 2nd patent - https://patents.google.com/patent/US2577234A/en 1st science paper - https://www.doi.org/10.1126/science.109.2832.359a 2nd science paper - https://www.doi.org/10.1126/science.109.2832.359.b anti-nausea discovery - https://www.doi.org/10.1126/science.109.2840.574.a Predicted pKa sources: 8-chlorotheophyline - https://www.chemicalbook.com/ProductChemicalPropertiesCB1401343_EN.htm theophylline - https://pubchem.ncbi.nlm.nih.gov/compound/Theophylline diphenhydramine - https://pubchem.ncbi.nlm.nih.gov/compound/Diphenhydramine ---------------------------------------------------------------------------------------------------------------------------------- I made this thumbnail with DOLL-E

This is the 21st chempilation. Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist Second Discord link if the first one is borked - https://discord.gg/QWNPETtPcZ I made this thumbnail with DOLL-E

This is the 20th chempilation - Check out even more Chempilations! https://www.youtube.com/playlist?list=PL6OLqxmk7Rtx_0L7pPT5tzLD7rT-93riO Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist Second Discord link if the first one is borked - https://discord.gg/QWNPETtPcZ Original video of the sodium explosion: https://www.youtube.com/watch?v=VgWiLjuLaq0 I made this thumbnail with DOLL-E

This is a totally normal video about chemicals and is educational - nothing special to see here. 👼 Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist Second Discord link if the first one is borked - https://discord.gg/QWNPETtPcZ Clitoriacetal Reference - http://doi.org/10.1016/S0031-9422(98)00235-0 Charlie's video - https://www.youtube.com/watch?v=fByMGbFUZxE Markiplier's video - https://www.youtube.com/watch?v=fBJ72GhkuFY Molecules for this tierlist - Benzo[k]fluoranthene, Skatole, Fucitol, TATP, Phosgene, Phthalic Acid, Clitoracital, Methanal, Urospermal, Orotic acid, Spermine, Spermidine, Tetraethyllead, Pimpinellin, Limaspermidine, Hymenin, Methamphetamine, Viagra, Bastardane, Fagomine, Vaginidiol, Naled, & Lactate

Take a look at the first pictures of perfluorocubane! In this video I discuss the recent synthesis of perfluorocubane. I want to give a huge thank you to Midori Akiyama and Masafumi Sugiyama for allowing me to share their beautiful photos of perfluorocubane and its precursors. For inquiries regarding these images, please contact [email protected] Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist Second Discord link if the first one is borked - https://discord.gg/QWNPETtPcZ ---------------------------------------------------------------------------------------------------------------------------------- Links to articles discussed in this episode: Perfluorocubane - https://www.doi.org/10.1126/science.abq0516 PERFECT fluorination - https://www.doi.org/10.1016/j.jfluchem.2014.09.020 Matrix radical cations - https://www.doi.org/10.1021/j100461a005 ----------------------------------------------------------------------------------------------------------------------------------

Get Surfshark VPN at https://surfshark.deals/CHEMIST - enter promo code CHEMIST for 83% off and 3 extra months for free! This video was sponsored by Surfshark. Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist Second Discord link if the first one is borked - https://discord.gg/QWNPETtPcZ

Always wear the appropriate PPE! This is the 19th chempilation. There is a 🌶 Patreon-exclusive chempilation that you might want to check out! Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist Second Discord link if the first one is borked - https://discord.gg/QWNPETtPcZ

In this video, I discuss five important papers in organic synthesis that were published in August 2022. Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist Backup Discord link - https://discord.gg/QWNPETtPcZ Lemieux-Johnson Oxidation - https://www.youtube.com/watch?v=KFB1dQ_dW8M ---------------------------------------------------------------------------------------------------------------------------------- Links to articles discussed in this episode: First Paper - https://www.doi.org/10.1126/science.abo6443 Second Paper - https://www.doi.org/10.1021/jacs.2c06024 Third Paper- https://www.doi.org/10.1021/jacs.2c05648 Leonori preprint - https://doi.org/10.21203/rs.3.rs-1590024/v1 Fourth Paper - https://www.doi.org/10.1021/jacs.2c06504 Fifth Paper - https://www.doi.org/10.1021/acs.orglett.2c02142 Alkynyltrifluoroborate Alkylation - https://www.doi.org/10.1021/acs.orglett.2c02507 Dearomative Silylation of Arenes - https://www.doi.org/10.1021/acs.joc.2c01178 Vinylogous and Bisvinylogous Propargylic Substitution - https://www.doi.org/10.1021/jacs.2c06560 Perfluorocubane - https://www.doi.org/10.1126/science.abq0516 Aza-Baeyer-Villiger - https://www.doi.org/10.1021/acs.orglett.2c02361 Other Total Synth - https://www.doi.org/10.1021/jacs.2c06738 Bpin-BCPs from NHPI Esters & B2Pin2 - https://www.doi.org/10.1038/s41557-022-00979-0 Photocatalytic Nickel-Mediated Amination of Aryl Halides - https://www.doi.org/10.1021/acs.joc.2c01284 ----------------------------------------------------------------------------------------------------------------------------------

Nitric acid is no joke! This is the 18th chempilation. Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist Second Discord link if the first one is borked - https://discord.gg/QWNPETtPcZ This is the Klein Bottle video - apparently he connected 17, not 11! https://www.youtube.com/watch?v=f-Pe1ZMJEXk

Warning - this episode contains a lot of humor. Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist Second Discord link if the first one is borked - https://discord.gg/QWNPETtPcZ

Be mindful of car batteries! This is the 17th chempilation. Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist Second Discord link if the first one is borked - https://discord.gg/QWNPETtPcZ

This is the 15th chempilation. Please dispose of your chemicals responsibly! Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist Second Discord link if the first one is borked - https://discord.gg/QWNPETtPcZ ChemicalForce has a video on LIQUID OZONE: https://www.youtube.com/watch?v=vttsvMKQ1Yw

This is the 100th upload to the channel! Thank you for your continued support - you are magnificent mouthpipetters! Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist Second Discord link if the first one is borked - https://discord.gg/QWNPETtPcZ Fungal Toxin Video: https://youtu.be/pkHTzVRVOp0 Mold Toxin Video: https://youtu.be/S4lyrevxwSA

This is the 14th chempilation. Some of these stories are pretty intense this time! Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist Second Discord link if the first one is borked - https://discord.gg/QWNPETtPcZ

This is the 13th chempilation. Don't repeat any of the stuff in the dumb stories! Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist Second Discord link if the first one is borked - https://discord.gg/QWNPETtPcZ

This is the 12th chempilation. We have some more insane stories submitted by you magnificent viewers! Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist Second Discord link if the first one is borked - https://discord.gg/QWNPETtPcZ

In this video, I decide which molecules are most cringe! Grimace is the best. https://www.patreon.com/thatchemist Community Discord - https://discord.gg/thatchemist Second Discord link if the first one is borked - https://discord.gg/QWNPETtPcZ

This is the 11th chempilation - Check out even more Chempilations! https://www.youtube.com/playlist?list=PL6OLqxmk7Rtx_0L7pPT5tzLD7rT-93riO Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/RBfrrPXF36

This is the 10th chempilation - Check out even more Chempilations! https://www.youtube.com/playlist?list=PL6OLqxmk7Rtx_0L7pPT5tzLD7rT-93riO Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist

Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist

I want to give a HUGE thanks to Frank, Frank's PI, Cyto and Leutthire for their contributions to this project! Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist ---------------------------------------------------------------------------------------------------------------------------------- Links to articles discussed in this episode: Hair paper - https://www.doi.org/10.1139/cjc-2019-0444 Nickel nanoparticle paper - https://www.doi.org/10.1016/j.mcat.2017.12.015 ----------------------------------------------------------------------------------------------------------------------------------

We can all help prevent suicide. National Suicide Prevention Lifeline (US) is available 24/7, accessible via phone or text 1-800-273-8255 (1-800-273-TALK) - also available by dialing 988 (US Only) or reach them online via chat or text: https://988lifeline.org/ https://www.healthline.com/health/mental-health-resources ------------------------------------------------------------------------------------------------------------------------------------ This is the 9th chempilation. Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist

This is the 8th chempilation - Check out even more Chempilations! https://www.youtube.com/playlist?list=PL6OLqxmk7Rtx_0L7pPT5tzLD7rT-93riO Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist

Sorry I accidentally deleted PVC - my bad :( Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist

In this video, I discuss five important papers in organic synthesis that were published in June 2022. Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist ---------------------------------------------------------------------------------------------------------------------------------- Links to articles discussed in this episode: Halogenation - https://www.doi.org/10.1021/jacs.2c06440 prior work - https://www.doi.org/10.1021/acs.joc.7b02920 Collybolide - https://www.doi.org/10.1021/acscentsci.2c00442 Trifluoromethylation - https://www.doi.org/10.1021/jacs.2c04807 Bipolamine I - https://www.doi.org/10.1021/jacs.2c06015 hydrogen autotransfer- https://www.doi.org/10.1021/acs.orglett.7b02336 Tricarbonyl-Ene - https://www.doi.org/10.1002/anie.202203311 Golec Oxidation - https://www.doi.org/10.1016/S0040-4039(00)60085-0 Benzoxazoles - https://www.doi.org/10.1021/acs.joc.2c00790 Cyclopropylamines - https://www.doi.org/10.1021/acs.orglett.2c01634 BCPs - https://www.doi.org/10.1021/jacs.2c05304 Inpyrfluxam - https://www.doi.org/10.1021/acs.oprd.2c00097 Indolylalcohols - https://www.doi.org/10.1021/jacs.2c02216 Sulfinimine Mannich - https://www.doi.org/10.1021/jacs.2c05368 Ar-CF2-[Si] - https://www.doi.org/10.1021/jacs.2c05044 ----------------------------------------------------------------------------------------------------------------------------------

The Column is a free email newsletter about how companies make chemicals at a global scale. You can get started for free by visiting https://thecolumn.co/?utm_source=tc001 This is the 7th chempilation - Check out even more Chempilations! https://www.youtube.com/playlist?list=PL6OLqxmk7Rtx_0L7pPT5tzLD7rT-93riO Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist ---------------------------------------------------------------------------------------------------------------------------------- Links to articles discussed in this episode: Enynenynols - https://www.doi.org/10.1021/ed074p782 ----------------------------------------------------------------------------------------------------------------------------------

These five compounds were the most amazing smelling molecules that I made during my PhD - I would recommend that you try smelling them, if you do so responsibly! Difluoroethers sometimes smell absolutely amazing! This video is a reupload. Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist --------------------------------------------------------------------------------------------------------------------------- Links to articles discussed in this episode: difluorobenzodioxole paper - https://doi.org/10.1021/acs.joc.0c01729 difluoroether paper - https://doi.org/10.1002/chem.201904132 SeCF3 paper - https://doi.org/10.1021/acs.orglett.2c00916 ---------------------------------------------------------------------------------------------------------------------------

This is the 6th chempilation - Check out even more Chempilations! https://www.youtube.com/playlist?list=PL6OLqxmk7Rtx_0L7pPT5tzLD7rT-93riO Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - discord.gg/thatchemist

In this video, I rank several common reagents that smell pretty good, but you probably shouldn't be smelling them! This video is a reupload. Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist

This is the 5th chempilation - Check out even more Chempilations! https://www.youtube.com/playlist?list=PL6OLqxmk7Rtx_0L7pPT5tzLD7rT-93riO Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist

Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist I know I say interesting too much - I will work on it ;)

Visit https://brilliant.org/ThatChemist/ to get started learning STEM for free, and the first 200 people will get 20% off their annual premium subscription. In this video, I discuss several mycotoxins found in molds. This video was sponsored by Brilliant. Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist ---------------------------------------------------------------------------------------------------------------------------------- Links to articles discussed in this episode: T-2 - https://www.doi.org/10.2903/j.efsa.2011.2481 T-2 tox - https://www.doi.org/10.1016/j.fct.2015.02.005 Diacetoxyscirpenol - https://www.selectagents.gov/sat/list.htm Diacetoxyscirpenol tox - https://www.doi.org/10.1016/B978-0-12-812026-2.00003-7 β-Nitropropionic acid - https://www.doi.org/10.1007/BF01575978 patulin genotoxicity - https://web.archive.org/web/20130815072813/http://www.fda.gov/Food/FoodborneIllnessContaminants/NaturalToxins/ucm212520.htm patulin tox - https://www.doi.org/10.1016/j.cofs.2015.10.003 patulin biosynth - https://www.doi.org/10.3390/toxins2040613 Alfatoxin B1 - https://www.doi.org/10.1128/br.30.2.460-470.1966 Sterigmatocystin - https://www.doi.org/10.3390/ijerph13090862 Fusaproliferin - https://www.doi.org/10.3390/toxins11060357 Fusaproliferin as a teratogen - https://www.doi.org/10.1021/jf960890v Fumonisin sphingosine mimicry - https://www.doi.org/10.1038/s41467-018-05613-7 Fumonisin folate uptake - https://www.doi.org/10.1038/nrn1986 Fumonisin cancer - https://www.doi.org/10.1289/ehp.01109s2239 ----------------------------------------------------------------------------------------------------------------------------------

I accidentally called the Liebig condenser a Claisen condenser (sorry). This video is a reupload. Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist

This is the 4th chempilation - Check out even more Chempilations! https://www.youtube.com/playlist?list=PL6OLqxmk7Rtx_0L7pPT5tzLD7rT-93riO Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist

In this video, I rank several common reagents that are so dangerous, they could end you. For fire extinguishers, A is for 'Ash', B is for 'barrel', and C is for 'current' (i.e. electrical fires). KH and related substances should be put out with a D fire extinguisher (the mnemonic is 'dynamite' which is kinda dumb IMO). Class K fire extinguishers are for oil fires in the 'kitchen'. This video is a reupload. Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist

These five compounds were the worst smelling molecules that I made during my PhD - I would not recommend that you try smelling them! isonitriles, cyanide, selenium compounds, phosphines, and fluorothionoformates are SO BAD. This video is a reupload. Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist ---------------------------------------------------------------------------------------------------------------------------------- Links to articles discussed in this episode: N-SCN - https://doi.org/10.1039/C9OB01340G (PPh)5 - https://doi.org/10.1021/jacs.7b09175 Woollins' - https://doi.org/10.1002/hc.520010502 ----------------------------------------------------------------------------------------------------------------------------------

In this video, I talk about some of your craziest research mishaps! This is the 3rd chempilation - Check out even more Chempilations! https://www.youtube.com/playlist?list=PL6OLqxmk7Rtx_0L7pPT5tzLD7rT-93riO Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist

In this video, I decide which aromatic heterocycles (heteroaromatic compounds) are the best! I misspoke - the MacMillan group developed an NHC reagent based off of benzoxazoles, not benzothiazoles. Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord - https://discord.gg/thatchemist ---------------------------------------------------------------------------------------------------------------------------------- Links to articles discussed in this episode: MacMillan Group's NHC Chemistry - https://www.doi.org/10.1038/s41586-021-03920-6 Phil Baran's Book - "The Portable Chemist's Consultant" - https://books.apple.com/us/book/the-portable-chemists-consultant/id618463142 The Baran Lab's YT Channel - https://www.youtube.com/channel/UCqfuQDFKYu63EmnCsNNOHSQ Heterobenzylic Fluorination Paper - https://www.doi.org/10.1039/C8SC01221K ----------------------------------------------------------------------------------------------------------------------------------

In this video, I present eight pink chemical compounds! Support the channel on Patreon - https://bit.ly/3yQjgYC Join the Community Discord! - https://discord.gg/thatchemist ---------------------------------------------------------------------------------------------------------------------------------- Links to articles discussed in this episode: Thiobenzoyl chloride - https://www.doi.org/10.1002/9780470771273.ch11 Rhodamine B - https://www.doi.org/10.1002/hlca.193702001143 Phenolphthalein - https://www.doi.org/10.1002/cber.18710040209 Bismuth Subsalicylate - https://patents.google.com/patent/US449520A/en Erythrosine toxicity - https://www.washingtonpost.com/archive/politics/1990/02/07/fda-red-dyes-reluctant-regulator/04320829-9727-4d2e-b3d5-53e9bbbca0dd/ Erythrosine synthesis - https://www.doi.org/10.1080/02652030600550747 Clofentezine mites - https://www.efsa.europa.eu/en/efsajournal/pub/6817 Clofentezine synthesis - https://www.doi.org/10.1016/j.bmcl.2006.04.066 ----------------------------------------------------------------------------------------------------------------------------------

In this video, I rank several common reagents that are so toxic, they could kill you. This video is a reupload. Support the Channel on Patreon: https://bit.ly/3yQjgYC Join the Community Discord! - https://discord.gg/thatchemist

In this video, I discuss several fungal mycotoxins! https://www.patreon.com/thatchemist Community Discord - https://discord.gg/thatchemist ---------------------------------------------------------------------------------------------------------------------------------- Links to articles discussed in this episode: Gyromitrin - https://www.doi.org/10.1016/S0041-0101(03)00238-1 Gyromitrin toxicity - https://www.doi.org/10.1093/jnci/60.1.201 Methyl hydrazine - https://www.doi.org/10.1002/jat.2550110403 Lolitrem B - https://www.doi.org/10.3390/toxins8020047 Satratoxin H - https://www.doi.org/10.1128/AEM.64.10.3620-3625.1998 https://en.wikipedia.org/wiki/Satratoxin-H Fusarin C - https://www.doi.org/10.1021/jf00125a031 Vomitoxin - https://www.doi.org/10.1007/s00204-010-0579-8 Ergotamine - https://www.doi.org/10.1046/j.1526-4610.2003.03034.x Diplonine - https://www.doi.org/10.1021/jf202735e Citrinin - https://www.doi.org/10.2478/10004-1254-60-2009-1992 Gliotoxin - https://www.doi.org/10.1007/s00253-011-3689-1 Fusarium verticillioides - https://www.doi.org/10.3390/jof7090694 Moniliformin - https://www.doi.org/10.4315/0362-028X-64.11.1780 ---------------------------------------------------------------------------------------------------------------------------------- Acknowledgements: -mfernflower (Anthony) from the Discord - we had many excellent discussions!

In this video, I discuss the chemistry of sunscreen! https://www.patreon.com/thatchemist Community Discord - https://discord.gg/thatchemist ---------------------------------------------------------------------------------------------------------------------------------- Links to articles discussed in this episode: https://cen.acs.org/business/consumer-products/What-in-sunscreen-and-how-does-it-protect-your-skin-from-the-sun-rays/99/i27 https://en.wikipedia.org/wiki/Sunburn https://www.fda.gov/drugs/understanding-over-counter-medicines/sunscreen-how-help-protect-your-skin-sun#ingredients Oxybenzone - https://www.doi.org/10.1111/1523-1747.ep12344991 photosensitizers - https://www.doi.org/10.1021/es2019675 https://en.wikipedia.org/wiki/Pyrimidine_dimer https://www.nature.com/articles/news.2008.537 https://oceanfdn.org/is-your-sunscreen-killing-coral-reefs/ https://www.colorescience.com/blogs/learn/how-does-sunscreen-work-to-protect-your-skin ---------------------------------------------------------------------------------------------------------------------------------- Acknowledgements: Yepoleb from the Discord - thanks for everything! Art_Is - for the oxybenzone paper!

In this video, I discuss five surprising reactions that I observed - chemical reactions often form unexpected products! This video is a reupload. https://www.patreon.com/thatchemist Community Discord - https://discord.gg/thatchemist ---------------------------------------------------------------------------------------------------------------------------------- Links to articles discussed in this episode: AgF review - https://doi.org/10.1002/047084289X.rs016.pub2 thia-Fries - https://doi.org/10.1016/S0022-1139(03)00106-4 ----------------------------------------------------------------------------------------------------------------------------------

In this video, I decide which molecules are most cursed! https://www.patreon.com/thatchemist Community Discord - https://discord.gg/QWNPETtPcZ

Visit https://brilliant.org/ThatChemist/ to get started learning STEM for free, and the first 200 people will get 20% off their annual premium subscription. In this video, I discuss the chemistry of skunk spray! This video was sponsored by Brilliant. https://www.patreon.com/thatchemist Community Discord - https://discord.gg/QWNPETtPcZ ---------------------------------------------------------------------------------------------------------------------------------- Links to articles discussed in this episode: Info for skunk spray frequency and volume - https://open.alberta.ca/dataset/7b9179c0-34e1-4b34-8309-145a71f238fe/resource/c20c0e5e-299b-4b87-810d-363d3be92642/download/2016-agri-facts-biology-and-control-of-skunks-agdex-684-5-revised-december-2016.pdf Comment on skunk behavior -https://parade.com/664736/marilynvossavant/do-skunks-spray-other-skunks/#:~:text=And%20as%20they%20rarely%20feel,and%20he%20slinks%20away%2C%20offended. Skunk history & volatiles paper - https://www.doi.org/10.1007/s00897990286a Other Skunk volatile paper - https://www.doi.org/10.1023/A:1020573404341 Comment about skunk musk - https://www.newscientist.com/article/mg12717282-900-science-the-seven-deadly-smells-of-a-skunk/ ---------------------------------------------------------------------------------------------------------------------------------- 0:00 Introduction 0:07 Spooky Skunk Info Skunks can spray up to 4-5 meters 1:47 Skunks Stink . The bad smell that skunks have primarily come from 2 thiols 3:19 Thioester Hydrolysis Mechanism . In this example, the nucleophile could be lots of possible things - amino acid residues in the skin/hair or water for example 5:10 Conjecture About Smell Persistence 6:13 Removing The Smell

In this video, I discuss some of the interesting mycotoxins produced by mushrooms! https://www.patreon.com/thatchemist Community Discord - https://discord.gg/QWNPETtPcZ ---------------------------------------------------------------------------------------------------------------------------------- Links to articles discussed in this episode: Tinky Winkenic Acid discovery - https://www.doi.org/10.1038/nchembio.179 Illudins - https://www.doi.org/10.1016/S1568-7864(02)00166-0 Ibotenic Acid - https://www.doi.org/10.1007/BF03159956 Muscimol - https://www.doi.org/10.2174/1568026023393525 Coprine - https://www.doi.org/10.1124/pr.111.005538 Coprine - ISBN 0-7167-2600-9 Muscarine - https://www.doi.org/10.1080/15563650903008448 Psilocybin & Psilocin - https://www.doi.org/10.1080/1355621021000005937 Orellanine - https://www.doi.org/10.1093/ndt/14.11.2779-a Agaritine - https://www.doi.org/10.1080/02652030210156340 Agaritine carcinogenicity - https://www.doi.org/10.1016/0278-6915(94)00142-B Amatoxins - https://www.doi.org/10.1007/BF00444032 ---------------------------------------------------------------------------------------------------------------------------------- 0:00 Introduction 0:07 Wild Mushrooms are Dangerous!!! . You should never consume random mushrooms 0:43 Triangulenic Acid (Tinky Winkenic Acid) . This toxin is found in Russula subnigricans 2:50 Ibotenic Acid & Muscimol . One of the most famous mushrooms - Amanita Muscaria 3:36 Coprine . Present in Coprinopsis atramentorio (the common ink cap) 5:43 Psilocybin & Psilocin . Famously know in mushrooms from the genus Psilocybe (magic mushrooms) 6:41 Orellanine . From the Orellani-e.g. Cortinarius rubellus (deadly webcap) 8:31 Amatoxins • Notably present in Amanita phalloides (the death cap) . The red substituents vary between amatoxins

In this video, I decide which acids are the best! There are many properties to consider! (This video is a reupload). https://www.patreon.com/thatchemist Community Discord - https://discord.gg/QWNPETtPcZ

In this video, I discuss the reasons why we reference certain types of papers. When does referencing matter? https://www.patreon.com/thatchemist Community Discord - https://discord.gg/QWNPETtPcZ ---------------------------------------------------------------------------------------------------------------------------------- Links to articles discussed in this episode: Our Paper - https://www.doi.org/10.1021/acs.orglett.0c00099 Naughty Nuggets - https://www.doi.org/10.1021/jacs.2c02611 ----------------------------------------------------------------------------------------------------------------------------------

In this video, I decide which solvents are the best! I consider their properties as solvents for chromatography, reactions, transferring as well as recrystallization. (This video is a reupload). Leave a comment down below if you have any chemicals that you think should be included next time! Let me know if you disagree with my assessments! Ok, so CO2 and benzene are not polar in terms of having a net dipole, but as a solvent, the polarity of their bonds (C=O polarized for CO2, and for benzene it is quadrupolar) is able to dissolve similar functional groups in polar molecules. https://www.patreon.com/thatchemist Community Discord - https://discord.gg/QWNPETtPcZ

In this video, I show you 6 yummy yellow chemicals! https://www.patreon.com/thatchemist Community Discord - https://discord.gg/QWNPETtPcZ ---------------------------------------------------------------------------------------------------------------------------------- Links to articles discussed in this episode: benzoquinone prep - https://patents.google.com/patent/US4973720A/en thionoesters - https://www.doi.org/10.1021/acs.joc.8b02260 pyridine chemistry - https://www.doi.org/10.1021/jacs.7b05414 ---------------------------------------------------------------------------------------------------------------------------------- 0:00 Introduction 0:13 Benzoquinone 1:08 Thionoesters 2:29 Diacetyl (2,3-Butanedione) 4:21 Potassium Dithioformate 6:34 Bromine Monochloride

In this video, we have another Figueroa paper! This is the fourth video in the series. We have all of the classics - cycloadditions of nitriles with alkynes, substitution of nitro groups, and some NMR data that really Hz. https://www.patreon.com/thatchemist Community Discord - https://discord.gg/QWNPETtPcZ ---------------------------------------------------------------------------------------------------------------------------------- Links to articles discussed in this episode: Figueroa Paper - https://www.doi.org/10.33263/BRIAC124.55675578 ----------------------------------------------------------------------------------------------------------------------------------

In this video, I discuss five important papers in organic synthesis that were published in June 2022. https://www.patreon.com/thatchemist Community Discord - https://discord.gg/QWNPETtPcZ ---------------------------------------------------------------------------------------------------------------------------------- Links to articles discussed in this episode: first paper - https://www.doi.org/10.1021/acs.oprd.2c00104 second paper - https://www.doi.org/10.1002/anie.202206176 third paper - https://www.doi.org/10.1002/anie.202205673 fourth paper - https://www.doi.org/10.1002/anie.202204319 fifth paper - https://www.doi.org/10.1021/jacs.2c03978 hydrazone reference - https://www.doi.org/10.1071/CH9711437 Suárez Oxidation - https://www.doi.org/10.1016/S0040-4039(01)90085-1 Ruthenium-mediated oxidation - https://www.doi.org/10.1002/asia.202000134 *Bonus Papers* Sulfonimidamides from sulfinamides - https://www.doi.org/10.1021/acs.orglett.2c01099 Really cool difunctionalization of 3,6-anhydrosugars - https://www.doi.org/10.1021/acs.orglett.2c01243 EJ Corey shows some neat reactions of nitrosyl triflate & nitrous anhydride - https://www.doi.org/10.1021/acs.orglett.2c01466 Aldehydes to ketone-functionalized BCPs (from [1.1.1]propellane) - https://www.doi.org/10.1021/acs.orglett.2c01707 Baran makes enantioenriched dialkylcarbinol esters with Ni cross-coupling - https://www.doi.org/10.1021/jacs.2c04358 Synthesis of Pleuromutilin - https://www.doi.org/10.1021/jacs.2c04708 ----------------------------------------------------------------------------------------------------------------------------------

In this video, I expose a really bad article from a really bad journal. (This is a reupload from the old channel). https://www.patreon.com/thatchemist Community Discord: https://discord.gg/QWNPETtPcZ ---------------------------------------------------------------------------------------------------------------------------------- Links to articles discussed in this episode: Sketchy Article - https://www.wjpr.net/abstract_file/1293 Bonus Sketchy Article - https://www.wjpr.net/abstract_file/4376 ----------------------------------------------------------------------------------------------------------------------------------

In this video, I show some of your greatest comments!!! This is the very first chempilation! Check out even more Chempilations! https://www.youtube.com/playlist?list=PL6OLqxmk7Rtx_0L7pPT5tzLD7rT-93riO https://www.patreon.com/thatchemist Community Discord - https://discord.gg/QWNPETtPcZ

In this video, I discuss one of the worst experiences that I ever had in my research career. (This is a reupload from the old channel). https://www.patreon.com/thatchemist Community Discord - https://discord.gg/QWNPETtPcZ ---------------------------------------------------------------------------------------------------------------------------------- Links to articles discussed in this episode: Deoxofluor paper - https://doi.org/10.1055/s-2002-35626 ----------------------------------------------------------------------------------------------------------------------------------

In this video, I reminisce about the time that I tried to make sodium tetrathiooxalate :( https://www.patreon.com/thatchemist Community Discord - https://discord.gg/QWNPETtPcZ ---------------------------------------------------------------------------------------------------------------------------------- Links to articles discussed in this episode: Amalgam article - https://www.doi.org/10.1002/cber.19270601120 DallE - https://huggingface.co/spaces/dalle-mini/dalle-mini ----------------------------------------------------------------------------------------------------------------------------------

In this video, I discuss how research conferences work! https://www.patreon.com/thatchemist Community Discord - https://discord.gg/QWNPETtPcZ

In this video, I discuss a retracted paper from Green Chemistry, where the authors use "magnetized water" for aromatic C-N bond formation. https://www.patreon.com/thatchemist Community Discord - https://discord.gg/QWNPETtPcZ ---------------------------------------------------------------------------------------------------------------------------------- Links to articles discussed in this episode: Retracted article - https://www.doi.org/10.1039/D0GC01329C ----------------------------------------------------------------------------------------------------------------------------------

In this video, I show 5 absolutely astonishing blue chemicals! https://www.patreon.com/thatchemist Community Discord - https://discord.gg/QWNPETtPcZ ---------------------------------------------------------------------------------------------------------------------------------- Links to articles discussed in this episode: https://en.wikipedia.org/wiki/Trifluoronitrosomethane https://upload.wikimedia.org/wikipedia/commons/8/86/Lactarius_indigo_48568_edit.jpg ChemicalForce Ozone - https://www.youtube.com/watch?v=ao4b_pEiYno NileRed Indigo - https://www.youtube.com/watch?v=6yhR242MnwA ----------------------------------------------------------------------------------------------------------------------------------

In this video, I discuss five really useful lab tricks, which makes your lab life a little bit easier :) https://www.patreon.com/thatchemist Community Discord - https://discord.gg/QWNPETtPcZ ----------------------------------------------------------------------------- Amazon Affiliate Link: Digital Thermocouple - https://amzn.to/3mNlcKo -----------------------------------------------------------------------------

In this video, I discuss many of the possible things that bad bosses do! Play along with a randomly generated Bingo card! Bingo: https://mfbc.us/m/zubh96s https://www.patreon.com/thatchemist Community Discord - https://discord.gg/QWNPETtPcZ

In this video, I discuss YET ANOTHER Figueroa paper. This time he manages to make really strained rings using ninhydrin, substituting TWO nitro groups. https://www.patreon.com/thatchemist Community Discord - https://discord.gg/QWNPETtPcZ ---------------------------------------------------------------------------------------------------------------------------------- Links to articles discussed in this episode: Sketchy Paper - https://www.doi.org/10.19261/cjm.2019.657 Ninhydrin review - https://www.doi.org/10.1002/047084289X.rn01848 Selenium paper - https://www.doi.org/10.1021/ol990791d ----------------------------------------------------------------------------------------------------------------------------------

In this video, I empirically decide which reducing agent is best! https://www.patreon.com/thatchemist Community Discord - https://discord.gg/QWNPETtPcZ

In this video, I discuss the https://www.patreon.com/thatchemist Community Discord - https://discord.gg/QWNPETtPcZ My AgNO3 stain (0.2 g AgNO3, dissolved in 10 mL H2O, 10 mL MeOH). It isn't too light sensitive - it will form a slight black precipitate, but this doesn't affect the quality of the stain). This stain is good for sulfur derivatives. ---------------------------------------------------------------------------------------------------------------------------------- Links to articles discussed in this episode: Great solvent group guide -https://www.yumpu.com/en/document/view/2214408/laboratory-chromatography-guide-buchi-labortechnik-gmbh NotVoodooX- http://www.chem.rochester.edu/notvoodoo/pages/chromatography.php?page=stains_dips A list of good stains - https://www.chemistry.mcmaster.ca/adronov/resources/Stains_for_Developing_TLC_Plates.pdf Seebach's magic stain: 25 g polymolybdic acid 10 g cerium (IV) sulfate 60 ml conc. H2SO4 940 ml H2O (from) https://www.scripps.edu/baran/images/grpmtgpdf/Holte_Feb_11.pdf ----------------------------------------------------------------------------------------------------------------------------------

In this video, I discuss some of the common mistakes that people make when they are doing labwork. https://www.patreon.com/thatchemist Community Discord - https://discord.gg/QWNPETtPcZ NotVoodooX - http://www.chem.rochester.edu/notvoodoo/pages/rookie_mistakes.php

In this video, I discuss the main considerations when preparing a supplemental information (for organic chemistry papers). https://www.patreon.com/thatchemist Community Discord - https://discord.gg/QWNPETtPcZ ---------------------------------------------------------------------------------------------------------------------------------- Links to articles discussed in this episode: Example 1 - https://www.doi.org/10.1039/C3CC43725F Example 2 - https://www.doi.org/10.1021/acs.orglett.9b02513 Example 3 - https://www.doi.org/10.1021/jacs.7b06044 Example 4 - https://www.doi.org/10.1021/ol500612n Example 5 - https://www.doi.org/10.1021/acs.orglett.7b03841 Example 6 - https://www.doi.org/10.1002/chem.201303699 Example 7 - https://www.doi.org/10.1002/anie.201002310 Example 8 - https://www.doi.org/10.1002/anie.201703841 ----------------------------------------------------------------------------------------------------------------------------------

In this video, I discuss another really bad paper from Super Figueroa! He once-again wows us with the magic he is able to do using acetonitrile - what an absolute legend. https://www.patreon.com/thatchemist Community Discord - https://discord.gg/QWNPETtPcZ ---------------------------------------------------------------------------------------------------------------------------------- Links to articles discussed in this episode: Super Figueroa - https://www.doi.org/10.1002/jhet.4189 ----------------------------------------------------------------------------------------------------------------------------------

In this video, I answer your questions! Make sure you leave a comment if you want me to do more Q&A's in the future! I had the wrong link for edX - it is edX.org https://www.patreon.com/thatchemist Community Discord - https://discord.gg/QWNPETtPcZ ---------------------------------------------------------------------------------------------------------------------------------- Links: Org Syn - http://www.orgsyn.org/demo.aspx?prep=cv6p1019 consulting email - [email protected] organic chemistry portal - https://www.organic-chemistry.org/ Baran Lab - https://www.youtube.com/channel/UCqfuQDFKYu63EmnCsNNOHSQ edX - https://www.edx.org/ ReactionFlash - https://apps.apple.com/us/app/reactionflash/id432080813 ----------------------------------------------------------------------------------------------------------------------------------

In this video, I discuss the use of... carrots as reducing agents for ketones. Yes this is real, no it isn't a joke, yes it is hilarious. I want to give a huge thank you to the members of the Discord that made this video possible! Conditions for the first reduction - 100 mg acetophenone, 70 ml water, 10 g carrot. Upon reprocessing the spectra, the ratio of product to SM was 62% prod/38% SM. https://www.patreon.com/thatchemist Community Discord - https://discord.gg/QWNPETtPcZ ---------------------------------------------------------------------------------------------------------------------------------- Links to articles discussed in this episode: Organic Chemistry Portal - https://www.organic-chemistry.org/chemicals/reductions/carrots.shtm JOC - https://www.doi.org/10.1021/jo010399p Org Lett - https://www.doi.org/10.1021/ol8029214 Ben List - https://www.doi.org/10.1055/s-0029-1216574 ----------------------------------------------------------------------------------------------------------------------------------

In this video, Tom and I rank several notable energetic compounds! Links to Tom's Channels: Explosions&Fire - https://www.youtube.com/c/ExplosionsFire2 Extractions&Ire - https://www.youtube.com/c/ExtractionsIre https://www.patreon.com/thatchemist Community Discord - https://discord.gg/QWNPETtPcZ

In this video, I discuss the prevalence of allylbenzene https://www.patreon.com/thatchemist Community Discord - https://discord.gg/QWNPETtPcZ ---------------------------------------------------------------------------------------------------------------------------------- Links to articles discussed in this episode: Cloves - https://www.doi.org/10.1021/jf060608c Sassafras - https://www.doi.org/10.1055/s-2006-959379 Anise - https://www.doi.org/10.1021/jf0257493 Fennel - https://www.doi.org/10.1080/0972060X.2011.10643978 Tarragon - https://www.doi.org/10.1177/1934578X1501000839 Parsley - https://www.doi.org/10.3390/foods5010018 Black Caraway - https://www.doi.org/10.1002/jsfa.3824 Octotea opifera Mart - https://www.doi.org/10.1080/10575630108041276 Croton hieronymi Root - https://www.doi.org/10.1080/10412905.2005.9698927 Chemistry of Spices Parthasarathy VA, Chempakam B, Zachariah TJ, editors. Cabi; 2008. ---------------------------------------------------------------------------------------------------------------------------------- ------- Amazon Affiliate Link: Napoleon's Buttons: 17 Molecules that Changed History https://amzn.to/3tgnK7t -------

In this video, I discuss the types of conflict that you may experience in the research lab, as well as methods of resolving them. https://www.patreon.com/thatchemist Community Discord - https://discord.gg/QWNPETtPcZ

In this video, I discuss how to record a presentation without having it look and sound like complete trash. This video was recorded without doing any editing whatsoever. https://www.patreon.com/thatchemist Community Discord - https://discord.gg/QWNPETtPcZ ------------------------------------------------------------------------------ Amazon Affiliate Links CAD Audio U37 USB Studio Condenser Recording Microphone - https://amzn.to/3x9pe65 Neewer Professional Microphone Pop Filter - https://amzn.to/3M0zGkp ------------------------------------------------------------------------------

In this video, I discuss the radical, nucleophilic, and electrophilic trifluoromethylation in C-CF3 bond forming reactions. https://www.patreon.com/thatchemist Community Discord - https://discord.gg/QWNPETtPcZ I forgot to mention in the video that the Ritter lab developed a TTF-CF3 reagent, which is promising as a versatile trifluoromethylating agent: https://doi.org/10.1021/jacs.1c02606 ---------------------------------------------------------------------------------------------------------------------------------- Links to articles discussed in this episode: Xe - https://www.doi.org/10.2174/978160805198410602010061 radical CF3 review - https://www.doi.org/10.1039/D1CS00200G OG Langlois - https://www.doi.org/10.1016/0040-4039(91)80524-A Langlois review - https://www.doi.org/10.1002/slct.202103867 Caffeine - https://www.doi.org/10.1073/pnas.1109059108 CF3SO2Cl - https://www.doi.org/10.1038/nature10647 CF3I - https://www.doi.org/10.1002/anie.201101861 TMS-CF3 review - https://www.doi.org/10.1021/cr400473a CuCF3 review - https://www.doi.org/10.1055/s-0037-1611776 Best CuCF3 - https://www.doi.org/10.1039/C6RA10302B cat. copper - https://www.doi.org/10.1002/chem.201405677 CF3H - https://www.doi.org/10.1126/science.1227859 Weibreb amide - https://www.doi.org/10.1039/C2CC35037H ketone - https://www.doi.org/10.1002/ejoc.201101038 acyl phosphonium - https://www.doi.org/10.1002/chem.202102854 Trifluoromethylator - https://www.doi.org/10.1002/anie.201100633 silane - https://www.doi.org/10.1002/anie.201601163 Umemoto review - https://www.doi.org/10.1039/C4OB00671B Togni review - https://www.doi.org/10.1021/cr500223h Sulfoximinine - https://www.doi.org/10.1002/chem.202005104 alkenes - https://www.doi.org/10.1021/ja401022x imidazolidinone - https://www.doi.org/10.1021/ja100748y ----------------------------------------------------------------------------------------------------------------------------------

In this video, I decide which oxidizers are best! https://www.patreon.com/thatchemist Community Discord - https://discord.gg/QWNPETtPcZ

In this video, I discuss the use of... unripe banana water as a 'medium' for the benzoylation of aniline... https://www.patreon.com/thatchemist Community Discord - https://discord.gg/QWNPETtPcZ ---------------------------------------------------------------------------------------------------------------------------------- Links to articles discussed in this episode: Banana Water Paper - https://www.doi.org/10.21767/2572-4657.100008 ----------------------------------------------------------------------------------------------------------------------------------

In this video, I discuss the formation of peroxides in common solvents. Make sure you check with the guidelines from your institutional EH&S department before dealing with peroxide-forming solvents! https://www.patreon.com/thatchemist Community Discord - https://discord.gg/QWNPETtPcZ ---------------------------------------------------------------------------------------------------------------------------------- Links to articles discussed in this episode: Diisopropyl ether bog - https://www.doi.org/10.1021/ed040p469 https://ehs.ucsc.edu/lab-safety-manual/specialty-chemicals/peroxide-formers-list.html https://ehs.ucsc.edu/lab-safety-manual/specialty-chemicals/peroxide-formers.html https://www.sfu.ca/content/dam/sfu/srs/work-research-safety/research-safety/Chemical%20safety/2019%20Chemical%20safety%20fact%20sheet%20peroxide%20formers.pdf https://www.sigmaaldrich.com/PA/en/technical-documents/technical-article/chemistry-and-synthesis/reaction-design-and-optimization/peroxide-formation https://ehs.berkeley.edu/news/peroxide-explosion-injures-campus-researcher Other J Chem Ed paper- https://www.doi.org/10.1021/ed013p494 ----------------------------------------------------------------------------------------------------------------------------------

In this video, I discuss five important papers in organic synthesis that were published in May 2022. https://www.patreon.com/thatchemist Community Discord - https://discord.gg/QWNPETtPcZ ---------------------------------------------------------------------------------------------------------------------------------- Links to articles discussed in this episode: first paper - https://www.doi.org/10.1021/acs.orglett.2c01174 second paper - https://www.doi.org/10.1021/acs.orglett.2c01410 third paper - https://www.doi.org/10.1021/jacs.2c02922 fourth paper - https://www.doi.org/10.1021/jacs.2c02795 fifth paper - https://www.doi.org/10.1038/s41586-022-04516-4 Bonus papers amino acid - https://www.doi.org/10.1021/acs.joc.2c00524 matteson - https://www.doi.org/10.1021/jacs.2c03621 cyclopropanone - https://www.doi.org/10.1021/jacs.2c03673 carborane - https://www.doi.org/10.1021/jacs.2c03031 hydrofluoroalkylation - https://www.doi.org/10.1021/acs.joc.2c00712 quinoline N-oxide - https://www.doi.org/10.1126/science.abo4282 ----------------------------------------------------------------------------------------------------------------------------------

In this video, I discuss the best way to dry THF, toluene, DCM, MeCN, methanol, ethanol, HMPA, DMF, DMSO, acetone, benzene, and 1,4-dioxane. https://www.patreon.com/thatchemist Community Discord - https://discord.gg/QWNPETtPcZ ---------------------------------------------------------------------------------------------------------------------------------- Links to articles discussed in this episode: newest paper - https://www.doi.org/10.1021/jo101589h https://www.doi.org/10.1021/jo00414a038 https://www.doi.org/10.1021/jo00438a024 ----------------------------------------------------------------------------------------------------------------------------------

In this video, I discuss the falsification of NMR spectra in published articles. I WAS INCORRECT - Janine Cossy was an editor for Organic Letters when her Organic Letters article was 'corrected'. She also had a paper in JOC which was 'corrected' around the same time. There is still a conflict of interest in my opinion, but it is important to note that she was an editor for a different journal when the falsified data for the JOC article was revised. https://www.patreon.com/thatchemist Community Discord - https://discord.gg/QWNPETtPcZ ---------------------------------------------------------------------------------------------------------------------------------- Links to articles discussed in this episode: retraction notice - https://www.doi.org/10.1021/jacs.0c11624 express of concern - https://www.doi.org/10.1021/jacs.0c02795 hydrodefluorination - https://www.doi.org/10.1021/jacs.7b06847 Type 1 from Chem Sci - https://www.doi.org/10.1039/C2SC20639K Type 1 from org lett - https://www.doi.org/10.1021/ol2015972 blog post - https://web.archive.org/web/20200820212832/http://blog.chembark.com/2013/08/19/some-very-peculiar-nmr-spectra-in-organic-letters/ 2nd blog post - https://web.archive.org/web/20150912170942/http://blog.chembark.com/wp-content/uploads/2013/08 Bonus Cossy article - https://www.doi.org/10.1021/jo300887u Correction from OBC - https://www.doi.org/10.1039/D0OB90089C 3rd blog post - https://retractionwatch.com/2019/03/06/a-university-thought-its-misconduct-investigation-was-complete-then-a-pubpeer-comment-appeared/ ----------------------------------------------------------------------------------------------------------------------------------

In this video, I decide which base is the best! Let me know down in the comments if you disagree with any of my assessments! https://www.patreon.com/thatchemist Community Discord - https://discord.gg/QWNPETtPcZ ------------------------------------------------------------------------------------------------------------------ Organic Letters Paper - https://doi.org/10.1021/acs.orglett.0c00099 ------------------------------------------------------------------------------------------------------------------

Dealing with failure is one of the most challenging struggles as a scientist - we all experience it, and it can be challenging to cope with failure. https://www.patreon.com/thatchemist Community Discord - https://discord.gg/QWNPETtPcZ

In this episode, I discuss oxidations with DMP, PCC, and Swern. Aldehydes are reactive intermediates, and methods for their synthesis are important! ---------------------------------------------------------------------------------------------------------------------------------- Links to articles discussed in this episode: first DMP - https://doi.org/10.1021/acs.joc.9b02378 second DMP - https://doi.org/10.1039/c1ob05612c third DMP - https://doi.org/10.1021/acs.orglett.5b01601 first PCC - https://patents.google.com/patent/WO2018068297A1/en second PCC - https://doi.org/10.3390/molecules23061422 first Swern - https://patents.google.com/patent/WO2012062157A1/en second Swern - https://doi.org/10.1016/0040-4039(90)80121-2 ---------------------------------------------------------------------------------------------------------------------------------- I hope you enjoyed the video! I'm planning on making a full series of videos if these videos are helpful for people! Recommended Texts: J. Clayden, N. Greeves, S. Warren, Organic Chemistry Second Edition, Oxford University Press, 2012. (especially good for mechanism and physical chemistry explanations) T. W. G. Solomons, C. B. Fryle, S. A. Snyder, Organic Chemistry Twelfth Edition, Wiley-VCH Verlag GmbH & Co. KGaA, 2016. LibreTexts: https://chem.libretexts.org/Bookshelves/Organic_Chemistry

In this video, I discuss the reduction of carbonyl compounds with sodium borohydride (NaBH4) and lithium aluminum hydride (LiAlH4). ---------------------------------------------------------------------------------------------------------------------------------- Links to articles discussed in this episode: NotVoodooX - http://www.chem.rochester.edu/notvoodoo/ NaBH4 review - https://doi.org/10.1002/047084289X.rs052.pub3 first NaBH4 - https://doi.org/10.1021/jacs.7b12260 second NaBH4 - https://doi.org/10.1002/anie.201700190 third NaBH4 - https://doi.org/10.1016/j.jfluchem.2004.12.006 Fieser workup - http://www.chem.rochester.edu/notvoodoo/pages/magic_formulas.php?page=aluminum_hydride_reduction first LAH - https://doi.org/10.1021/ja0469030 second LAH - https://doi.org/10.1021/jo301790q third LAH - https://doi.org/10.1002/ajoc.201600429 alkyl halide LAH - https://doi.org/10.1021/jo00341a018 ---------------------------------------------------------------------------------------------------------------------------------- I hope you enjoyed the video! I'm planning on making a full series of videos if these videos are helpful for people! Recommended Texts: J. Clayden, N. Greeves, S. Warren, Organic Chemistry Second Edition, Oxford University Press, 2012. (especially good for mechanism and physical chemistry explanations) T. W. G. Solomons, C. B. Fryle, S. A. Snyder, Organic Chemistry Twelfth Edition, Wiley-VCH Verlag GmbH & Co. KGaA, 2016. LibreTexts: https://chem.libretexts.org/Bookshelves/Organic_Chemistry

In this video, I discuss Mukaiyama Aldol reactions, in addition to Boron Aldol reactions. Boron enolates can be prepared with really good E/Z selectivity, often much better than TMS-enolates. ---------------------------------------------------------------------------------------------------------------------------------- Links to articles discussed in this episode: base choice - https://doi.org/10.1021/jo00268a037 Mukaiyama - https://www.organic-chemistry.org/namedreactions/mukaiyama-aldol-addition.shtm boron aldol - https://doi.org/10.1021/jo00020a025 kinetic boron enolate - https://doi.org/10.1021/ja00191a058 thermodynamic boron enolate - https://doi.org/10.1021/jo00020a025 tms-enolates from boron enolates - https://doi.org/10.1016/S0040-4039(00)94175-3 ---------------------------------------------------------------------------------------------------------------------------------- I hope you enjoyed the video! I'm planning on making a full series of videos if these videos are helpful for people! Recommended Texts: J. Clayden, N. Greeves, S. Warren, Organic Chemistry Second Edition, Oxford University Press, 2012. (especially good for mechanism and physical chemistry explanations) T. W. G. Solomons, C. B. Fryle, S. A. Snyder, Organic Chemistry Twelfth Edition, Wiley-VCH Verlag GmbH & Co. KGaA, 2016. LibreTexts: https://chem.libretexts.org/Bookshelves/Organic_Chemistry

*Disclaimer* LDA can also afford E-enolates, and usually a mixture is obtained; if an ester or an amide is used instead of a ketone, the selectivity can change! Depending on the ketone that is used, the selectivity can also reverse. ---------------------------------------------------------------------------------------------------------------------------------- Links to articles discussed in this episode: first lithium aldol - https://doi.org/10.1039/D0SC06223E second lithium aldol - https://doi.org/10.1002/chem.201502754 Ben List - https://doi.org/10.1021/ja994280y Nobel Prize - https://www.nobelprize.org/prizes/chemistry/2021/list/lecture/ proline aldol example - https://doi.org/10.1126/science.abb3231 ---------------------------------------------------------------------------------------------------------------------------------- I hope you enjoyed the video! I'm planning on making a full series of videos if these videos are helpful for people! Recommended Texts: J. Clayden, N. Greeves, S. Warren, Organic Chemistry Second Edition, Oxford University Press, 2012. (especially good for mechanism and physical chemistry explanations) T. W. G. Solomons, C. B. Fryle, S. A. Snyder, Organic Chemistry Twelfth Edition, Wiley-VCH Verlag GmbH & Co. KGaA, 2016. LibreTexts: https://chem.libretexts.org/Bookshelves/Organic_Chemistry

In this video, I discuss aldol condensation reactions between aldehydes and ketones, which produce Michael acceptors (alpha-beta unsaturated carbonyl compounds). ---------------------------------------------------------------------------------------------------------------------------------- Links to articles discussed in this episode: N-parameter database - https://www.cup.lmu.de/oc/mayr/reaktionsdatenbank2 ---------------------------------------------------------------------------------------------------------------------------------- I hope you enjoyed the video! I'm planning on making a full series of videos if these videos are helpful for people! Recommended Texts: J. Clayden, N. Greeves, S. Warren, Organic Chemistry Second Edition, Oxford University Press, 2012. (especially good for mechanism and physical chemistry explanations) T. W. G. Solomons, C. B. Fryle, S. A. Snyder, Organic Chemistry Twelfth Edition, Wiley-VCH Verlag GmbH & Co. KGaA, 2016. LibreTexts: https://chem.libretexts.org/Bookshelves/Organic_Chemistry

If you like the way I explained the concept of 1,4-addition using electrophilicity and nucleophilicity parameters, let me know in the comments!! ---------------------------------------------------------------------------------------------------------------------------------- Links to articles discussed in this episode: N-parameter database - https://www.cup.lmu.de/oc/mayr/reaktionsdatenbank2 Mayr's website - https://www.cup.uni-muenchen.de/oc/mayr/research.html sulfur addition - https://doi.org/10.1021/jo00112a025 nitrogen addition - https://patents.google.com/patent/WO2012028331A1/en enolate addition - https://doi.org/10.1021/jo01031a059 enamine addition - https://doi.org/10.1002/mrc.1270220705 ---------------------------------------------------------------------------------------------------------------------------------- I hope you enjoyed the video! I'm planning on making a full series of videos if these videos are helpful for people! Recommended Texts: J. Clayden, N. Greeves, S. Warren, Organic Chemistry Second Edition, Oxford University Press, 2012. (especially good for mechanism and physical chemistry explanations) T. W. G. Solomons, C. B. Fryle, S. A. Snyder, Organic Chemistry Twelfth Edition, Wiley-VCH Verlag GmbH & Co. KGaA, 2016. LibreTexts: https://chem.libretexts.org/Bookshelves/Organic_Chemistry

I hope you enjoyed the video! I'm planning on making a full series of videos if these videos are helpful for people! ---------------------------------------------------------------------------------------------------------------------------------- Links to articles discussed in this episode: enolate formation - https://doi.org/10.1021/jo00268a037 ---------------------------------------------------------------------------------------------------------------------------------- Recommended Texts: J. Clayden, N. Greeves, S. Warren, Organic Chemistry Second Edition, Oxford University Press, 2012. (especially good for mechanism and physical chemistry explanations) T. W. G. Solomons, C. B. Fryle, S. A. Snyder, Organic Chemistry Twelfth Edition, Wiley-VCH Verlag GmbH & Co. KGaA, 2016. LibreTexts: https://chem.libretexts.org/Bookshelves/Organic_Chemistry

I hope you enjoyed the video! I'm planning on making a full series of videos if these videos are helpful for people! ---------------------------------------------------------------------------------------------------------------------------------- Links to articles discussed in this episode: cuprate addition - https://doi.org/10.1002/0471264180.or019.01 cuprate alkylation - https://doi.org/10.1021/ja00195a042 ketone formation - https://doi.org/10.1016/S0040-4039(00)89398-3 ---------------------------------------------------------------------------------------------------------------------------------- Recommended Texts: J. Clayden, N. Greeves, S. Warren, Organic Chemistry Second Edition, Oxford University Press, 2012. (especially good for mechanism and physical chemistry explanations) T. W. G. Solomons, C. B. Fryle, S. A. Snyder, Organic Chemistry Twelfth Edition, Wiley-VCH Verlag GmbH & Co. KGaA, 2016. LibreTexts: https://chem.libretexts.org/Bookshelves/Organic_Chemistry

I hope you enjoyed the video! I'm planning on making a full series of videos if these videos are helpful for people! ---------------------------------------------------------------------------------------------------------------------------------- Links to articles discussed in this episode: CH3Li - https://doi.org/10.1002/047084289X.rm205.pub2 Lithium alkynide - https://doi.org/10.1055/s-0035-1560587 C-H lithiation example - https://doi.org/10.1002/047084289X.rm205.pub2 nBuLi - https://doi.org/10.1002/047084289X.rb395.pub2 ---------------------------------------------------------------------------------------------------------------------------------- Recommended Texts: J. Clayden, N. Greeves, S. Warren, Organic Chemistry Second Edition, Oxford University Press, 2012. (especially good for mechanism and physical chemistry explanations) T. W. G. Solomons, C. B. Fryle, S. A. Snyder, Organic Chemistry Twelfth Edition, Wiley-VCH Verlag GmbH & Co. KGaA, 2016. LibreTexts: https://chem.libretexts.org/Bookshelves/Organic_Chemistry

I hope you enjoyed the video! I'm planning on making a full series of videos if these videos are helpful for people! Recommended Texts: J. Clayden, N. Greeves, S. Warren, Organic Chemistry Second Edition, Oxford University Press, 2012. (especially good for mechanism and physical chemistry explanations) T. W. G. Solomons, C. B. Fryle, S. A. Snyder, Organic Chemistry Twelfth Edition, Wiley-VCH Verlag GmbH & Co. KGaA, 2016. LibreTexts: https://chem.libretexts.org/Bookshelves/Organic_Chemistry

Here is the link to the Organic Syntheses article using trimethyl orthoformate: http://orgsyn.org/demo.aspx?prep=v75p0170 I hope you enjoyed the video! I'm planning on making a full series of videos if these videos are helpful for people! Recommended Texts: J. Clayden, N. Greeves, S. Warren, Organic Chemistry Second Edition, Oxford University Press, 2012. (especially good for mechanism and physical chemistry explanations) T. W. G. Solomons, C. B. Fryle, S. A. Snyder, Organic Chemistry Twelfth Edition, Wiley-VCH Verlag GmbH & Co. KGaA, 2016. LibreTexts: https://chem.libretexts.org/Bookshelves/Organic_Chemistry

I hope you enjoyed the video! I'm planning on making a full series of videos if these videos are helpful for people! Recommended Texts: J. Clayden, N. Greeves, S. Warren, Organic Chemistry Second Edition, Oxford University Press, 2012. (especially good for mechanism and physical chemistry explanations) T. W. G. Solomons, C. B. Fryle, S. A. Snyder, Organic Chemistry Twelfth Edition, Wiley-VCH Verlag GmbH & Co. KGaA, 2016. LibreTexts: https://chem.libretexts.org/Bookshelves/Organic_Chemistry

I hope you enjoyed the video! I'm planning on making a full series of videos if these videos are helpful for people! Recommended Texts: J. Clayden, N. Greeves, S. Warren, Organic Chemistry Second Edition, Oxford University Press, 2012. (especially good for mechanism and physical chemistry explanations) T. W. G. Solomons, C. B. Fryle, S. A. Snyder, Organic Chemistry Twelfth Edition, Wiley-VCH Verlag GmbH & Co. KGaA, 2016. LibreTexts: https://chem.libretexts.org/Bookshelves/Organic_Chemistry

I hope you enjoyed the video! I'm planning on making a full series of videos if these videos are helpful for people! Recommended Texts: J. Clayden, N. Greeves, S. Warren, Organic Chemistry Second Edition, Oxford University Press, 2012. (especially good for mechanism and physical chemistry explanations) T. W. G. Solomons, C. B. Fryle, S. A. Snyder, Organic Chemistry Twelfth Edition, Wiley-VCH Verlag GmbH & Co. KGaA, 2016. LibreTexts: https://chem.libretexts.org/Bookshelves/Organic_Chemistry

I hope you enjoyed the video! I'm planning on making a full series of videos if these videos are helpful for people! Recommended Texts: J. Clayden, N. Greeves, S. Warren, Organic Chemistry Second Edition, Oxford University Press, 2012. (especially good for mechanism and physical chemistry explanations) T. W. G. Solomons, C. B. Fryle, S. A. Snyder, Organic Chemistry Twelfth Edition, Wiley-VCH Verlag GmbH & Co. KGaA, 2016. LibreTexts: https://chem.libretexts.org/Bookshelves/Organic_Chemistry

I hope you enjoyed the video! I'm planning on making a full series of videos if these videos are helpful for people! Recommended Texts: J. Clayden, N. Greeves, S. Warren, Organic Chemistry Second Edition, Oxford University Press, 2012. (especially good for mechanism and physical chemistry explanations) T. W. G. Solomons, C. B. Fryle, S. A. Snyder, Organic Chemistry Twelfth Edition, Wiley-VCH Verlag GmbH & Co. KGaA, 2016. LibreTexts: https://chem.libretexts.org/Bookshelves/Organic_Chemistry

I hope you enjoyed the video! I'm planning on making a full series of videos if these videos are helpful for people! Recommended Texts: J. Clayden, N. Greeves, S. Warren, Organic Chemistry Second Edition, Oxford University Press, 2012. (especially good for mechanism and physical chemistry explanations) T. W. G. Solomons, C. B. Fryle, S. A. Snyder, Organic Chemistry Twelfth Edition, Wiley-VCH Verlag GmbH & Co. KGaA, 2016. LibreTexts: https://chem.libretexts.org/Bookshelves/Organic_Chemistry

I hope you enjoyed the video! I'm planning on making a full series of videos if these videos are helpful for people! Recommended Texts: J. Clayden, N. Greeves, S. Warren, Organic Chemistry Second Edition, Oxford University Press, 2012. (especially good for mechanism and physical chemistry explanations) T. W. G. Solomons, C. B. Fryle, S. A. Snyder, Organic Chemistry Twelfth Edition, Wiley-VCH Verlag GmbH & Co. KGaA, 2016. LibreTexts: https://chem.libretexts.org/Bookshelves/Organic_Chemistry

I hope you enjoyed the video! I'm planning on making a full series of videos if these videos are helpful for people! Recommended Texts: J. Clayden, N. Greeves, S. Warren, Organic Chemistry Second Edition, Oxford University Press, 2012. (especially good for mechanism and physical chemistry explanations) T. W. G. Solomons, C. B. Fryle, S. A. Snyder, Organic Chemistry Twelfth Edition, Wiley-VCH Verlag GmbH & Co. KGaA, 2016. LibreTexts: https://chem.libretexts.org/Bookshelves/Organic_Chemistry

I hope you enjoyed the video! I'm planning on making a full series of videos if these videos are helpful for people! Recommended Texts: J. Clayden, N. Greeves, S. Warren, Organic Chemistry Second Edition, Oxford University Press, 2012. (especially good for mechanism and physical chemistry explanations) T. W. G. Solomons, C. B. Fryle, S. A. Snyder, Organic Chemistry Twelfth Edition, Wiley-VCH Verlag GmbH & Co. KGaA, 2016. LibreTexts: https://chem.libretexts.org/Bookshelves/Organic_Chemistry

I hope you enjoyed the video! I'm planning on making a full series of videos if these videos are helpful for people! Recommended Texts: J. Clayden, N. Greeves, S. Warren, Organic Chemistry Second Edition, Oxford University Press, 2012. (especially good for mechanism and physical chemistry explanations) T. W. G. Solomons, C. B. Fryle, S. A. Snyder, Organic Chemistry Twelfth Edition, Wiley-VCH Verlag GmbH & Co. KGaA, 2016. LibreTexts: https://chem.libretexts.org/Bookshelves/Organic_Chemistry

I hope you enjoyed the video! I'm planning on making a full series of videos if these videos are helpful for people!

I hope you enjoyed the video! I'm planning on making a full series of videos if these videos are helpful for people! I mistakenly labeled diethyl sulfide as propanethiol. Recommended Texts: J. Clayden, N. Greeves, S. Warren, Organic Chemistry Second Edition, Oxford University Press, 2012. (especially good for mechanism and physical chemistry explanations) T. W. G. Solomons, C. B. Fryle, S. A. Snyder, Organic Chemistry Twelfth Edition, Wiley-VCH Verlag GmbH & Co. KGaA, 2016. LibreTexts: https://chem.libretexts.org/Bookshelves/Organic_Chemistry

In this video, I go through the use of Mendeley as a reference manager, which enables the rapid assembly of bibliographies, with the correct formatting and information, through the use of DOIs. I also briefly feature Sci-Hub. Medlife Crisis has a good video on Sci-Hub: https://www.youtube.com/watch?v=PriwCi6SzLo free reference manager (Mendeley) - http://mendeley.com/ Sci-Hub - sci-hub.se